EVALUATION OF 4-AMINO SALICYLIC ACID CHELATING EFFECT ON HEALING OF MANGANESE INDUCED INTOXICATIONS IN MALE WISTAR RAT'S LIVER

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RAZAVIAN M.H.; TAMADDON N.; ESLAMI FARSANI M.; ZOLFAGHARI M.R.; YADEGARI S.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2012 | Volume:14 | Issue:4 Page(s): 11-20

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Title

EVALUATION OF 4-AMINO SALICYLIC ACID CHELATING EFFECT ON HEALING OF MANGANESE INDUCED INTOXICATIONS IN MALE WISTAR RAT'S LIVER

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Keywords

MANGANESEQ2

PARA AMINO SALICYLIC ACIDQ3

LIVER INTOXICATIONQ2

Abstract

Background and aims: MANGANESE related jobs (Mn miners) may cause Manganism, a Parkinson like disease. Chelators are suggested to reduce these effects. This study was carried out to investigate the effect of 4-Amino Salicylic acid chelating effects.Methods: This experimental study was done on 20 adult male Wistar rats. The rats were classified into four groups, 5 in each group, as follows: one control and three experimental groups. In two phases the groups received Salin-Salin, MANGANESE-Salin, Salin-4-Amino acid and MANGANESE -4-Amini acid, respectively. Eight mg/kg of MANGANESE chloride i.p. injection for 1 week and 1.5 g/l of PAS s.c injection five-day in a week for four weeks, were used for intoxication and treatment, respectively. Serum and liver tissues were separated. Data were analyzed using ANOVA and Tukey's tests.Results: Biochemical factors showed cholesterol increment in group 2 compared with group 1 and decrement of cholesterol level in the blood of group 4 compare with group 2 (P<0.01). Also increasing the direct billirubin in the Mn and PAS groups was more significant compared with control group (P<0.05). Billirubin was observed in the urine of the Mn, PAS, Mn+PAS groups and urobilinogen declining was decreased in the urine of these groups (P<0.05). There was a significant increase (P<0.05) of OT, PT enzymes in the serum of PAS and ALP in the Mn and Mn+PAS groups compared with control group.Conclusion: PAS can play a significant role in reducing destructive effects of Mn, especially on liver but has different side effects, like other chemical drugs.

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APA: Copy

RAZAVIAN, M.H., TAMADDON, N., ESLAMI FARSANI, M., ZOLFAGHARI, M.R., & YADEGARI, S.. (2012). EVALUATION OF 4-AMINO SALICYLIC ACID CHELATING EFFECT ON HEALING OF MANGANESE INDUCED INTOXICATIONS IN MALE WISTAR RAT'S LIVER. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 14(4), 11-20. SID. https://sid.ir/paper/58614/en

Vancouver: Copy

RAZAVIAN M.H., TAMADDON N., ESLAMI FARSANI M., ZOLFAGHARI M.R., YADEGARI S.. EVALUATION OF 4-AMINO SALICYLIC ACID CHELATING EFFECT ON HEALING OF MANGANESE INDUCED INTOXICATIONS IN MALE WISTAR RAT'S LIVER. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(4):11-20. Available from: https://sid.ir/paper/58614/en

IEEE: Copy

M.H. RAZAVIAN, N. TAMADDON, M. ESLAMI FARSANI, M.R. ZOLFAGHARI, and S. YADEGARI, “EVALUATION OF 4-AMINO SALICYLIC ACID CHELATING EFFECT ON HEALING OF MANGANESE INDUCED INTOXICATIONS IN MALE WISTAR RAT'S LIVER,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4, pp. 11–20, 2012, [Online]. Available: https://sid.ir/paper/58614/en

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