EFFECTS OF ALCOHOLIC EXTRACT OF PEGANUMHARMALA L. ON MALONDIALDEHYDE CONCENTRATION AND CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITY IN MICE TREATED WITH NANO SILVER PARTICLES

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KARAM SICHANI SAMIRA; NAGHSH NOOSHIN; RAZMI NEMATALLAH

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Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:95 Page(s): 10-17

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Title

EFFECTS OF ALCOHOLIC EXTRACT OF PEGANUMHARMALA L. ON MALONDIALDEHYDE CONCENTRATION AND CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITY IN MICE TREATED WITH NANO SILVER PARTICLES

Author(s)

KARAM SICHANI SAMIRA | NAGHSH NOOSHIN | RAZMI NEMATALLAH | Issue Writer Certificate

Keywords

NANO SILVER

PEGANUMHARMALA

CATALASE

GLUTATHIONE PEROXIDASE

MALONDIALDEHYDE J MAZAND

Abstract

Background and purpose: NANO SILVER particles are associated with oxidative stress due to free radical production. Long-term use of antioxidant agents could result in harmful production of free radicals. This study assessed the protective and antioxidant effects of PEGANUMHARMALA L.onmalemicetreated with NANO SILVER particles.Materials and methods: In this study 32 male Albino mice (25-30gr) were divided into four groups, one control group and three intervention groups. The intervention groups included a group receiving 500 ppm NANO SILVER particles, a group fed 20 mg/kg/day by ethanolic extract of P.harmala for 30 days, and a group which was given ethanolic extract of P.harmala orally and the same dose of nanosilver particles. Onthreeconsecutive day sat the beginning of the experiment intraperitoneal injections of NANO SILVER were performed. Post-treatment blood samples were collected from the hearts and the activity of serum CATALASE (CAT) and GLUTATHIONE PEROXIDASE (GPx) I nredblood cell and concentration of serummalondialdehyde (MDA) were determined.Results: In the mice treated with NANO SILVER particles the MDA concentration significantly increased, while significant decreases were seen in GPx and CAT activities (P<0.001). However, P.harmalaextract reversed these effects i.e. it increased GPx and CAT activities and decreased the MDA level significantly (P<0.001).Conclusion: The ethanolic extract of P. harmala with antioxidant properties is believed to decrease thefreeradicals produced by silvernanoparticles.

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APA: Copy

KARAM SICHANI, SAMIRA, NAGHSH, NOOSHIN, & RAZMI, NEMATALLAH. (2012). EFFECTS OF ALCOHOLIC EXTRACT OF PEGANUMHARMALA L. ON MALONDIALDEHYDE CONCENTRATION AND CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITY IN MICE TREATED WITH NANO SILVER PARTICLES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(95), 10-17. SID. https://sid.ir/paper/586362/en

Vancouver: Copy

KARAM SICHANI SAMIRA, NAGHSH NOOSHIN, RAZMI NEMATALLAH. EFFECTS OF ALCOHOLIC EXTRACT OF PEGANUMHARMALA L. ON MALONDIALDEHYDE CONCENTRATION AND CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITY IN MICE TREATED WITH NANO SILVER PARTICLES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(95):10-17. Available from: https://sid.ir/paper/586362/en

IEEE: Copy

SAMIRA KARAM SICHANI, NOOSHIN NAGHSH, and NEMATALLAH RAZMI, “EFFECTS OF ALCOHOLIC EXTRACT OF PEGANUMHARMALA L. ON MALONDIALDEHYDE CONCENTRATION AND CATALASE AND GLUTATHIONE PEROXIDASE ACTIVITY IN MICE TREATED WITH NANO SILVER PARTICLES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 95, pp. 10–17, 2012, [Online]. Available: https://sid.ir/paper/586362/en

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