مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SAFETY ASSESSMENT OFOCIMUM BASILICUM HYDROALCOHOLIC EXTRACT IN WISTAR RATS: ACUTE AND SUBCHRONIC TOXICITY STUDIES

Pages

  645-653

Abstract

 Objective(s): OCIMUM BASILICUML. is widely used in folk medicine of many countries including Iran. Both O. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. Therefore, in the present study, acute and SUBCHRONIC TOXICITY ofO. basilicum hydroalcohlic extract have been evaluated in Wistar RATS.Materials and Methods: For the ACUTE TOXICITY assessment, five groups of 10 animals (5 male, 5 female) received four different single dose of extract orally, the animals were, then, kept under observation for 14 days. For SUBCHRONIC TOXICITY, the animals were divided into four groups (5 male, 5 female) and were gavaged daily by 50, 200 and 500 mg/kg of extract. Mortality, clinical signs, body weight changes, food and water consumption, and hematological and biochemical parameters were monitored during the study period. On the 45th day, animals were sacrificed and gross findings, weight of liver and left kidney and liver histological markers were assessed.Results: The results of acute study indicated that LD50 of O. basilicum is higher than 5 mg/kg. In subchronic study, no adverse effects were observed on serum parameters in male and female RATS. The hematological results showed a reduction in the hematocrit, platelets and RBC in both sexes. No abnormalities were observed in other parameters.Conclusion: Based on the results of this study, present data suggest that hematologic system could serve as a target organ in oral toxicity of this plant.

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    APA: Copy

    RASEKH, HAMID REZA, HOSSEINZADEH, LEILA, MEHRI, SOGHRA, MOHAMMAD, KAMLI NEJAD, ASLANI, MAJID, & TANBAKOOSAZAN, FARAHNAZ. (2012). SAFETY ASSESSMENT OFOCIMUM BASILICUM HYDROALCOHOLIC EXTRACT IN WISTAR RATS: ACUTE AND SUBCHRONIC TOXICITY STUDIES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(1), 645-653. SID. https://sid.ir/paper/587197/en

    Vancouver: Copy

    RASEKH HAMID REZA, HOSSEINZADEH LEILA, MEHRI SOGHRA, MOHAMMAD KAMLI NEJAD, ASLANI MAJID, TANBAKOOSAZAN FARAHNAZ. SAFETY ASSESSMENT OFOCIMUM BASILICUM HYDROALCOHOLIC EXTRACT IN WISTAR RATS: ACUTE AND SUBCHRONIC TOXICITY STUDIES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(1):645-653. Available from: https://sid.ir/paper/587197/en

    IEEE: Copy

    HAMID REZA RASEKH, LEILA HOSSEINZADEH, SOGHRA MEHRI, KAMLI NEJAD MOHAMMAD, MAJID ASLANI, and FARAHNAZ TANBAKOOSAZAN, “SAFETY ASSESSMENT OFOCIMUM BASILICUM HYDROALCOHOLIC EXTRACT IN WISTAR RATS: ACUTE AND SUBCHRONIC TOXICITY STUDIES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 1, pp. 645–653, 2012, [Online]. Available: https://sid.ir/paper/587197/en

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