PRODUCTION, QUALITY CONTROL AND BIODISTRIBUTION STUDIES OF 166HO-EDTMP THERAPEUTIC RADIOPHARMACEUTICAL

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BAGHERI REZA; BAHRAMI SAMANI ALI; SHIRVANI ARANI SIMINDOKHT; GHANNADI MARAGHEH MOHAMMAD

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Journal Paper

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2010 | Volume:18 | Issue:SUPPLEMENT 1 Page(s): 144-144

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Title

PRODUCTION, QUALITY CONTROL AND BIODISTRIBUTION STUDIES OF 166HO-EDTMP THERAPEUTIC RADIOPHARMACEUTICAL

Author(s)

BAGHERI REZA | BAHRAMI SAMANI ALI | SHIRVANI ARANI SIMINDOKHT | GHANNADI MARAGHEH MOHAMMAD

Keywords

BONE METASTASES

166HO-EDTMP

RADIOPHARMACEUTICAL

BIODISTRIBUTION

Abstract

Introduction: Bone metastases are a frequent complication of cancer that frequently causes intense pain. Pain palliation of these cancers is one of important goals in nuclear medicine. Therapeutic radiopharmaceuticals are widely used to palliate pain of bone metastases. Among some radiopharmaceuticals which are useful for radiotherapy, holmium-166 ethylenediamine-tetramethylenephosphonicacid (166Ho-EDTMP) is of particular interest for larger tumors.166Ho is a beta and gamma emitter with a high beta energy and appropriate halflife and gamma ray (81 keV) for imaging studies.Methods: 166Ho was prepared by neutron activation of natural 165Ho sample (purity >99/8%) and complex was obtained in room temperature by adding EDTMP ligand. In this research radiochemical purity was checked by paper chromatography and radionuclidic purity by recording the gamma ray spectra using a gamma spectrometer with an HPGe detector. The biodistribution studies of radiopharmaceutical, then was performed using wild type rats. In addition, the image was taken at 4 hours after administration of the radiopharmaceutical by a dual-head SPECT system.Results: 166Ho-EDTMP was prepared in excellent purity (above 99% in 30 minutes) and with high in-vitro stability. The major deposition of radiopharmaceutical (>70%) was found in bone, while radiopharmaceutical did not practically accumulate in other organs.Conclusion: 166Ho-EDTMP is a promising agent for bone pain palliation therapy in skeletal metastases in human with low undesired dose to other organs in rodents.

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APA: Copy

BAGHERI, REZA, BAHRAMI SAMANI, ALI, SHIRVANI ARANI, SIMINDOKHT, & GHANNADI MARAGHEH, MOHAMMAD. (2010). PRODUCTION, QUALITY CONTROL AND BIODISTRIBUTION STUDIES OF 166HO-EDTMP THERAPEUTIC RADIOPHARMACEUTICAL. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(SUPPLEMENT 1), 144-144. SID. https://sid.ir/paper/590603/en

Vancouver: Copy

BAGHERI REZA, BAHRAMI SAMANI ALI, SHIRVANI ARANI SIMINDOKHT, GHANNADI MARAGHEH MOHAMMAD. PRODUCTION, QUALITY CONTROL AND BIODISTRIBUTION STUDIES OF 166HO-EDTMP THERAPEUTIC RADIOPHARMACEUTICAL. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(SUPPLEMENT 1):144-144. Available from: https://sid.ir/paper/590603/en

IEEE: Copy

REZA BAGHERI, ALI BAHRAMI SAMANI, SIMINDOKHT SHIRVANI ARANI, and MOHAMMAD GHANNADI MARAGHEH, “PRODUCTION, QUALITY CONTROL AND BIODISTRIBUTION STUDIES OF 166HO-EDTMP THERAPEUTIC RADIOPHARMACEUTICAL,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. SUPPLEMENT 1, pp. 144–144, 2010, [Online]. Available: https://sid.ir/paper/590603/en

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