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Information Journal Paper

Title

EFFECT OF ERYTHROPOIETIN ON SERUM BRAIN-DERIVED BIOMARKERS AFTER CARBON MONOXIDE POISONING IN RATS

Pages

  752-758

Abstract

 Objective(s): ERYTHROPOIETIN has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S100b, as a glial damage marker and MYELIN BASIC PROTEIN (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of ERYTHROPOIETIN (EPO) on serum S100b and MBP levels after CO poisoning in RATs. Materials and Methods: RATs were poisoned with a mixture of 3000 PPM CO in air for 65 min. After exposure, half of the RATs received 5000 u/kg EPO and the rest received normal saline. At 3, 6, 12, 24, 48, 72, 144, and 336 hr after exposure samples were taken. Additionally, EPO was administered at three lower doses (625, 1250 and 2500 u/kg). The serum S100b and MBP levels were measured using immunoenzymatic colorimetric assay. Hemoglobin level was alsomeasured. Results Serum S100b levels in CO poisoned RATs were significantly higher compared to the control group [6 hr (P<0.01), 12 hr (P<0.001), 24 hr (P<0.001), 48 hr (P<0.008) and 72 hr (P<0.008)]. EPO administration could significantly prevent serum S100b elevations after 12 hr (P<0.008) and 24 hr (P<0.008) of CO poisoning. Serum MBP levels in CO poisoned RATs were not significantly increased in comparison with the control group (P>0.05). EPO significantly increased the hemoglobin levels.Conclusion EPO could partially prevent neuronal damage. More studies are required to elucidate other aspects of these effects.

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    APA: Copy

    SHAHSAVAND, SHABNAM, MOHAMMADPOUR, AMIR HOOSHANG, REZAEE, RAMIN, BEHRAVAN, EFFAT, SAKHTIANCHI, RAMIN, & MOALLEM, SEYED ADEL. (2012). EFFECT OF ERYTHROPOIETIN ON SERUM BRAIN-DERIVED BIOMARKERS AFTER CARBON MONOXIDE POISONING IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(2), 752-758. SID. https://sid.ir/paper/591286/en

    Vancouver: Copy

    SHAHSAVAND SHABNAM, MOHAMMADPOUR AMIR HOOSHANG, REZAEE RAMIN, BEHRAVAN EFFAT, SAKHTIANCHI RAMIN, MOALLEM SEYED ADEL. EFFECT OF ERYTHROPOIETIN ON SERUM BRAIN-DERIVED BIOMARKERS AFTER CARBON MONOXIDE POISONING IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(2):752-758. Available from: https://sid.ir/paper/591286/en

    IEEE: Copy

    SHABNAM SHAHSAVAND, AMIR HOOSHANG MOHAMMADPOUR, RAMIN REZAEE, EFFAT BEHRAVAN, RAMIN SAKHTIANCHI, and SEYED ADEL MOALLEM, “EFFECT OF ERYTHROPOIETIN ON SERUM BRAIN-DERIVED BIOMARKERS AFTER CARBON MONOXIDE POISONING IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 2, pp. 752–758, 2012, [Online]. Available: https://sid.ir/paper/591286/en

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