THE PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE DONOR (L-ARGININE) IN CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCES IN RAT MODEL

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ESHRAGHI JAZI FATEMEH; NEMATBAKHSH MEHDI; NASRI HAMID; TALEBI ARDESHIR; HAGHIGHI MARYAM; PEZESHKI ZAHRA; SAFARI TAHEREH; ASHRAFI FARZANEH

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:11 Page(s): 1389-1396

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Title

THE PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE DONOR (L-ARGININE) IN CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCES IN RAT MODEL

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Keywords

GENDER

L-ARGININE

CISPLATIN

NEPHROTOXICITY

RAT

Abstract

BACKGROUND: CISPLATIN (CP) as a potential drug for solid tumors produces NEPHROTOXICITY and disturbs endothelial function. CP induced NEPHROTOXICITY may be GENDER related. Nitric oxide plays a pivotal role in endothelial function and L-ARGININE as endogenous NO donor promotes endothelial function. The role of L-ARGININE in CP induced NEPHROTOXICITY model and its GENDER related was investigated in this study.METHODS: Thirty three Wistar RATs were randomly assigned to four groups. The groups 1 (male, n=6) and 2 (female, n=11) received a single dose of L-ARGININE (300 mg/kg, ip), and the day after, they received a single dose of CP (7 mg/kg). The group 3 (male, n=9) and 4 (female, n=7) were assigned to the same regimen except for saline instead of L-ARGININE. All animals were sacrificed one week after CP administration. The levels of blood urea nitrogen (BUN), creatinine and nitrite were measured. The kidneys were also removed for pathological investigations.RESULTS: Five animals died. All CP treated animals lost weight. The normalized weigh loss was significantly different between male and female in CP+L-arginine treated animals (p<0.05). BUN and creatinine were increased significantly in male treated with CP and in female treated with CP+L-arginine (p<0.05). L-ARGININE reduced BUN in male (not in female) when compared with control groups (p<0.05). The level of nitrite was increased significantly in L-ARGININE treated animals. Kidney tissue damage score and normalized kidney weight were greater in females treated with CP+ L-ARGININE than female received CP alone (p<0.05).CONCLUSIONS: L-ARGININE may protect against CP induced NEPHROTOXICITY in male, but it promotes the induced damage in female. The exact mechanism need to be defined.

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APA: Copy

ESHRAGHI JAZI, FATEMEH, NEMATBAKHSH, MEHDI, NASRI, HAMID, TALEBI, ARDESHIR, HAGHIGHI, MARYAM, PEZESHKI, ZAHRA, SAFARI, TAHEREH, & ASHRAFI, FARZANEH. (2011). THE PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE DONOR (L-ARGININE) IN CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCES IN RAT MODEL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(11), 1389-1396. SID. https://sid.ir/paper/592132/en

Vancouver: Copy

ESHRAGHI JAZI FATEMEH, NEMATBAKHSH MEHDI, NASRI HAMID, TALEBI ARDESHIR, HAGHIGHI MARYAM, PEZESHKI ZAHRA, SAFARI TAHEREH, ASHRAFI FARZANEH. THE PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE DONOR (L-ARGININE) IN CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCES IN RAT MODEL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(11):1389-1396. Available from: https://sid.ir/paper/592132/en

IEEE: Copy

FATEMEH ESHRAGHI JAZI, MEHDI NEMATBAKHSH, HAMID NASRI, ARDESHIR TALEBI, MARYAM HAGHIGHI, ZAHRA PEZESHKI, TAHEREH SAFARI, and FARZANEH ASHRAFI, “THE PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE DONOR (L-ARGININE) IN CISPLATIN-INDUCED NEPHROTOXICITY: GENDER RELATED DIFFERENCES IN RAT MODEL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 11, pp. 1389–1396, 2011, [Online]. Available: https://sid.ir/paper/592132/en

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