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Information Journal Paper

Title

INVESTIGATION THE ROLE OF GENDER ON THE HLA-DRB1 AND -DQB1 ASSOCIATION WITH TYPE 1 DIABETES MELLITUS IN IRANIAN PATIENTS

Pages

  108-115

Abstract

 Objective: TYPE 1 DIABETES mellitus (T1D) is an autoimmune and multifactorial disorder. Subsequent analysis on human leukocyte antigen (HLA) region shows that HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, for the first time, we investigated the influence of GENDER on the HLA-DRB1 and -DQB1 association with TYPE 1 DIABETES mellitus in Iranian patients in order to determine GENDER dependent HLA heterogeneity in Iranian T1D patients.Materials and Methods: In this case control study, the HLA-DRB1 and -DQB1 typing were performed on 105 Iranian T1D patients and 100 healthy controls. The data were evaluated by using Fisher exact test.Results: Our results indicate that DRB1*04:01, DQB1*03:02 alleles and DRB1*04:01-DQB1*03:02 haplotype were significantly more frequent in male T1D patients than females. Also, DRB1*03:01, DRB1*15:01, DQB1*06:01 alleles, DQB1*03:01/05:01 genotype, DRB1*03:01-DQB1*02:01 and DRB1*15:01-DQB1*06:01 haplotypes were significantly higher in female T1D group than males. Furthermore, our results showed that DRB1*04:01 and DQB1*03:02 alleles were significantly more frequent in male T1D patients 1-5 years old at onset than females with similar condition. The DRB1*03:01 allele and DRB1*03:01-DQB1*02:01 haplotype were significantly higher in female T1D patients 6-10 years old at onset than males with similar condition. The DRB1*15:01 allele and DRB1*15:01-DQB1*06:01 haplotype were significantly more frequent in female T1D patients 16-20 years old at onset than males with similar condition.Conclusion: Our findings suggest that GENDER has a significant influence on the distribution of HLA-DR and -DQ alleles, genotypes and haplotypes. Also, distribution of the HLA-DRB1 and -DQB1 alleles, genotypes and haplotypes vary based on the GENDER of T1D patients in different AGE AT ONSET.

Cites

References

Cite

APA: Copy

SAYAD, AREZOU, AKBARI, MOHAMMAD TAGHI, PAJOUHI, MOHAMMAD, MOSTAFAVI, FERIDOON, KAZEMNEJAD, ANOOSHIRVAN, & ZAMANI, MAHDI. (2013). INVESTIGATION THE ROLE OF GENDER ON THE HLA-DRB1 AND -DQB1 ASSOCIATION WITH TYPE 1 DIABETES MELLITUS IN IRANIAN PATIENTS. CELL JOURNAL (YAKHTEH), 15(2 (58)), 108-115. SID. https://sid.ir/paper/596454/en

Vancouver: Copy

SAYAD AREZOU, AKBARI MOHAMMAD TAGHI, PAJOUHI MOHAMMAD, MOSTAFAVI FERIDOON, KAZEMNEJAD ANOOSHIRVAN, ZAMANI MAHDI. INVESTIGATION THE ROLE OF GENDER ON THE HLA-DRB1 AND -DQB1 ASSOCIATION WITH TYPE 1 DIABETES MELLITUS IN IRANIAN PATIENTS. CELL JOURNAL (YAKHTEH)[Internet]. 2013;15(2 (58)):108-115. Available from: https://sid.ir/paper/596454/en

IEEE: Copy

AREZOU SAYAD, MOHAMMAD TAGHI AKBARI, MOHAMMAD PAJOUHI, FERIDOON MOSTAFAVI, ANOOSHIRVAN KAZEMNEJAD, and MAHDI ZAMANI, “INVESTIGATION THE ROLE OF GENDER ON THE HLA-DRB1 AND -DQB1 ASSOCIATION WITH TYPE 1 DIABETES MELLITUS IN IRANIAN PATIENTS,” CELL JOURNAL (YAKHTEH), vol. 15, no. 2 (58), pp. 108–115, 2013, [Online]. Available: https://sid.ir/paper/596454/en

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