مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECTS OF PERIPHERAL AND INTRA-HIPPOCAMPAL ADMINISTRATION OF SODIUM SALICYLATE ON SPATIAL LEARNING AND MEMORY OF RATS

Pages

  709-718

Abstract

 Objective(s): CYCLOOXYGENASEs (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since SODIUM SALICYLATE is an inhibitor of COX, we have evaluated the effect of peripheral and intra hippocampal administration of SODIUM SALICYLATE on spatial learning and memory in male RATs. Materials and Methods: Male RATs were studied in two groups, the first group received different intra peritoneal (i.p.) SODIUM SALICYLATE doses (0, 200, 300, and 400 mg/kg) and the second group received intra-hippocampal doses of the drug (0, 30, 50, and 100 μg/0.5 ml/side). The spatial performance of RATs was tested using Morris water maze (MWM) task. The spatial learning and memory parameters were analyzed using ANOVA. Results: Peripheral and intra-hippocampal administration of SODIUM SALICYLATE did not lead to a statistically significant change in the mean time (escape latency), and also the distance traveled for finding the hidden platform during the training days, compared with the control group. But at the probe trial, the percentage of time spent in the target quadrant by RATs which received the highest doses of drug significantly increased. Conclusion: We found that both peripheral and intra-hippocampal administration of SODIUM SALICYLATE facilitates the process of SPATIAL MEMORY consolidation in the MWM.

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    APA: Copy

    AZIMI, LEILA, POURMOTABBED, ALI, GHADAMI, MOHAMMAD RASOOL, NEDAEI, SEYED ERSHAD, & POURMOTABBED, TARGOL. (2012). EFFECTS OF PERIPHERAL AND INTRA-HIPPOCAMPAL ADMINISTRATION OF SODIUM SALICYLATE ON SPATIAL LEARNING AND MEMORY OF RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(2), 709-718. SID. https://sid.ir/paper/599327/en

    Vancouver: Copy

    AZIMI LEILA, POURMOTABBED ALI, GHADAMI MOHAMMAD RASOOL, NEDAEI SEYED ERSHAD, POURMOTABBED TARGOL. EFFECTS OF PERIPHERAL AND INTRA-HIPPOCAMPAL ADMINISTRATION OF SODIUM SALICYLATE ON SPATIAL LEARNING AND MEMORY OF RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(2):709-718. Available from: https://sid.ir/paper/599327/en

    IEEE: Copy

    LEILA AZIMI, ALI POURMOTABBED, MOHAMMAD RASOOL GHADAMI, SEYED ERSHAD NEDAEI, and TARGOL POURMOTABBED, “EFFECTS OF PERIPHERAL AND INTRA-HIPPOCAMPAL ADMINISTRATION OF SODIUM SALICYLATE ON SPATIAL LEARNING AND MEMORY OF RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 2, pp. 709–718, 2012, [Online]. Available: https://sid.ir/paper/599327/en

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