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Information Journal Paper

Title

THE POLG GENE POLYMORPHISM IN IRANIAN VARICOCELE-ASSOCIATED INFERTILITY PATIENTS

Pages

  739-744

Abstract

 Objective(s): VARICOCELE is associated with impaired testicular function and male INFERTILITY, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian VARICOCELE patients. Materials and Methods: We determined the POLG CAG repeat length in DNA samples extracted from 40 VARICOCELE patients and 30 control subjects by PCR-denature polyacrylamide gel electrophoresis and sequencing. Results: The distribution of the CAG repeat length in VARICOCELE patients showed no notable difference from that in control subjects, but we found a significant statistical inverse correlation between 10/10 and 10/#10 genotypes and VARICOCELE grade. Conclusion: These findings indicate that POLG CAG repeats may affects the VARICOCELE grade, but the mechanisms remain to be elucidated.

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  • Cite

    APA: Copy

    HEIDARI, MOHAMMAD MEHDI, KHATAMI, MEHRI, & TALEBI, ALI REZA. (2012). THE POLG GENE POLYMORPHISM IN IRANIAN VARICOCELE-ASSOCIATED INFERTILITY PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(2), 739-744. SID. https://sid.ir/paper/599328/en

    Vancouver: Copy

    HEIDARI MOHAMMAD MEHDI, KHATAMI MEHRI, TALEBI ALI REZA. THE POLG GENE POLYMORPHISM IN IRANIAN VARICOCELE-ASSOCIATED INFERTILITY PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(2):739-744. Available from: https://sid.ir/paper/599328/en

    IEEE: Copy

    MOHAMMAD MEHDI HEIDARI, MEHRI KHATAMI, and ALI REZA TALEBI, “THE POLG GENE POLYMORPHISM IN IRANIAN VARICOCELE-ASSOCIATED INFERTILITY PATIENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 2, pp. 739–744, 2012, [Online]. Available: https://sid.ir/paper/599328/en

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