COMPARING THE EFFECTS OF REMIFENTANIL AND ALFENTANIL ON THE CARDIOVASCULAR RESPONSES TO THE INDUCTION OF ANESTHESIA AND TRACHEAL INTUBATION IN ELDERLY PATIENTS

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AKHAVAN AKBARI GH.; ENTEZARIASL M.; AMANI F.

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Journal: Journal of Ardabil University of Medical Sciences Year:2006 | Volume:6 | Issue:3 (21) Page(s): 220-226

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Information Journal Paper

Title

COMPARING THE EFFECTS OF REMIFENTANIL AND ALFENTANIL ON THE CARDIOVASCULAR RESPONSES TO THE INDUCTION OF ANESTHESIA AND TRACHEAL INTUBATION IN ELDERLY PATIENTS

Author(s)

AKHAVAN AKBARI GH. | ENTEZARIASL M. | AMANI F. | Issue Writer Certificate

Keywords

ALFENTANILQ3

REMIFENTANILQ3

HEMODYNAMICQ2

LARYNGOSCOPYQ2

TRACHEAL INTUBATIONQ3

Abstract

Background and Objectives: LARYNGOSCOPY and TRACHEAL INTUBATION could lead to HEMODYNAMIC responses in the form of hypertension and tachycardia as well as arrhythmia and myocardial ischemia. These alterations can be life-threatening particularly in elderly people. This clinical trial compared the effects of two rapid-onset narcotics, ALFENTANIL and REMIFENTANIL, on the HEMODYNAMIC responses to the induction and TRACHEAL INTUBATION in elderly patients.Methods: This double-blind clinical trial was conducted on 40 subjects aged 65 and above. They were candidates of cataract surgery under general anesthesia. The patients were randomly allocated to two groups of 20. The first group, was given ALFENTANIL 10 mg/kg and for second group REMIFENTANIL 0.5 mg/kg was injected prior to the induction of anesthesia. Both groups were similiar in the method of anesthesia except in narcotics. The first group was infused with ALFENTANIL 1 mg/kg/min and REMIFENTANIL 0.1 mg/kg/min was used for the second group. HEMODYNAMIC variations including heart rate, systolic, diastolic and mean arterial blood pressure were measured and recorded eight times (before induction, aften injection, after intubation and five times during anesthesia). Data were analyzed with SPSS software using descriptive and analytical statistics such as T-test, Chi squre and ANOVA. Results: Immediately after injection of narcotic drugs, all HEMODYNAMIC variants decreased. Howerver, diastolic blood pressure in Remifentantil group was significantly more than ALFENTANIL group (P<0.05). After LARYNGOSCOPY and TRACHEAL INTUBATION all HEMODYNAMIC variants increased and slowly decreased in less than 10 minutes. Systolic, diastolic and mean arterial blood pressure decreased significantly more in REMIFENTANIL group than ALFENTANIL group (P<0.05). Although heart rate decreased during few minutes after intubation, there was not significant difference between two groups regarding this decrease (P>0.05). Ephedrin was used to treat severe hypotention in those under REMIFENTANIL (11 patients) more than those under ALFENTANIL (4 patients) (P<0.05). Conclusions: According to the results of this study REMIFENTANIL could prevent HEMODYNAMIC variation induced by LARYNGOSCOPY and treacheal intubation more than ALFENTANIL. However in some cases REMIFENTANIL leads to hypotension during anesthesia. There is no important difference between two drugs in increasing heart rate after LARYNGOSCOPY and intubation.

Cites

COMPARISON OF THE EFFECT OF LIDOCAINE SPRAY ON BLADE OF LARYNGOSCOPE WITH INTRAVENOUS LIDOCAINE ON THE CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

References

A COMPARISON OF THE HEMODYNAMIC CHANGES AND RECOVERY TIME OF PROPOFOL AND REMIFENTANIL WITH PROPOFOL AND ALFENTAILIN CATARCAT SURGERY ANESTHESIA

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APA: Copy

AKHAVAN AKBARI, GH., ENTEZARIASL, M., & AMANI, F.. (2006). COMPARING THE EFFECTS OF REMIFENTANIL AND ALFENTANIL ON THE CARDIOVASCULAR RESPONSES TO THE INDUCTION OF ANESTHESIA AND TRACHEAL INTUBATION IN ELDERLY PATIENTS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 6(3 (21)), 220-226. SID. https://sid.ir/paper/60086/en

Vancouver: Copy

AKHAVAN AKBARI GH., ENTEZARIASL M., AMANI F.. COMPARING THE EFFECTS OF REMIFENTANIL AND ALFENTANIL ON THE CARDIOVASCULAR RESPONSES TO THE INDUCTION OF ANESTHESIA AND TRACHEAL INTUBATION IN ELDERLY PATIENTS. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2006;6(3 (21)):220-226. Available from: https://sid.ir/paper/60086/en

IEEE: Copy

GH. AKHAVAN AKBARI, M. ENTEZARIASL, and F. AMANI, “COMPARING THE EFFECTS OF REMIFENTANIL AND ALFENTANIL ON THE CARDIOVASCULAR RESPONSES TO THE INDUCTION OF ANESTHESIA AND TRACHEAL INTUBATION IN ELDERLY PATIENTS,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 6, no. 3 (21), pp. 220–226, 2006, [Online]. Available: https://sid.ir/paper/60086/en

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