BETA GLOBIN FRAMEWORKS IN THALASSEMIA MAJOR PATIENTS FROM NORTH IRAN

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AKHAVAN NIAKI HALEH; BANI HASHEMI ALI; AZIZI MANDANA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pediatrics Year:2012 | Volume:22 | Issue:3 Page(s): 297-302

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Information Journal Paper

Title

BETA GLOBIN FRAMEWORKS IN THALASSEMIA MAJOR PATIENTS FROM NORTH IRAN

Author(s)

AKHAVAN NIAKI HALEH | BANI HASHEMI ALI | AZIZI MANDANA | Issue Writer Certificate

Keywords

BETA–GLOBIN

THALASSEMIA

POLYMORPHISM

DENATURING GRADIENT GEL ELECTROPHORESIS

Abstract

Objective: Four combinations of five neutral sequence changes at rs713040, rs10768683, rs7480526, rs7946748, and rs1609812 occurring in the human beta globin gene defined as frameworks have been reported in beta globin gene. Here we report for the frequency of these frameworks in THALASSEMIA major patients of North Iran.Methods: Beta globin gene frameworks of 46 THALASSEMIA major patients of North Iran were determined using DENATURING GRADIENT GEL ELECTROPHORESIS.Findings: All these frameworks called framework 1, 2, 3, 3a were present at the frequency of 23.9%, 45.7%, 6.5% and 23.9% respectively.Conclusion: These frameworks may be used for tracking mutant alleles in prenatal diagnosis programs.

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APA: Copy

AKHAVAN NIAKI, HALEH, BANI HASHEMI, ALI, & AZIZI, MANDANA. (2012). BETA GLOBIN FRAMEWORKS IN THALASSEMIA MAJOR PATIENTS FROM NORTH IRAN. IRANIAN JOURNAL OF PEDIATRICS, 22(3), 297-302. SID. https://sid.ir/paper/603502/en

Vancouver: Copy

AKHAVAN NIAKI HALEH, BANI HASHEMI ALI, AZIZI MANDANA. BETA GLOBIN FRAMEWORKS IN THALASSEMIA MAJOR PATIENTS FROM NORTH IRAN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2012;22(3):297-302. Available from: https://sid.ir/paper/603502/en

IEEE: Copy

HALEH AKHAVAN NIAKI, ALI BANI HASHEMI, and MANDANA AZIZI, “BETA GLOBIN FRAMEWORKS IN THALASSEMIA MAJOR PATIENTS FROM NORTH IRAN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 22, no. 3, pp. 297–302, 2012, [Online]. Available: https://sid.ir/paper/603502/en

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