PITUITARY-THYROID AXIS FUNCTION AND CALCIUM-PHOSPHOR METABOLISM IN MAJOR THALASSEMIC PATIENTS, HORMOZGAN, IRAN

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HADAEGH FARZAD; ZARE SH.; TOUHIDI MARYAM; SAFA O.; MAHOURI KH.

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Journal: Hormozgan Medical Journal Year:2002 | Volume:6 | Issue:2 Page(s): 1-6

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Title

PITUITARY-THYROID AXIS FUNCTION AND CALCIUM-PHOSPHOR METABOLISM IN MAJOR THALASSEMIC PATIENTS, HORMOZGAN, IRAN

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Keywords

THYROID HORMONESQ4

THALASSEMIAQ3

CALCIUMQ3

HORMOZGANQ3

Abstract

Endocrine gland dysfunction in the background of iron retention is major problem in thalassemic patients. In order to assess the prevalence of thyroid dysfunction, CALCIUM and phosphate metabolism in thalassemic patients, a total number of 104randomlyselected, 7 to 21 years old thalassemic patients, were compared with 107age matched healthy individuals. The results revealed that 86% of thalassemic patients had ferritin level of greater than 1500 mg/ml. Prevalence of goiter in girls of both patient and healthy groups were 74%and 42%, respectively(P< .05), but this figure was not significantly different in boys. T4 and Ff41 level averages in patients were significantly less than those in healthy individuals (P< .05), while T3 and TSH levels were not significantly different. The results show that of 47% of thalassemic patients (3 girls and 2 boys) suffered from sub-clinical hypothyroid (TSH>5 and normal T4 and F T4I) and 9.1% of patients (6 girls and 4 boys) had normal TSH and deficiency in FT4I, which may be due to central hypothyroidism or Sick Euthyroid Syndrome (SES). 13.8% of thalassemic patients had abnormalities of pituitary-thyroid axis, while there was no Relationship between ferritin level and thyroid indexes. CALCIUM averages in boys of both case and control groups were significantly different (8.7 mg/dl vs. 9.2 mg/dl), but it was not different in girls. Phosphor level in boys and girls of case group was significantly higher than in control group (p< .0001). CALCIUM level of less than 8.1 mg/dl was detected in 27.6% of patients and it was shown also that risk of hypocalcaemia increases as age increases (r = -0.33, P<0.05). The results of this study shows that, in HORMOZGAN province (with sufficient iodine intake), the prevalence of hypo-thyroidism in thalassemic patients are relatively low, but prevalence of hypo-calceumia needs more investigations.

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APA: Copy

HADAEGH, FARZAD, ZARE, SH., TOUHIDI, MARYAM, SAFA, O., & MAHOURI, KH.. (2002). PITUITARY-THYROID AXIS FUNCTION AND CALCIUM-PHOSPHOR METABOLISM IN MAJOR THALASSEMIC PATIENTS, HORMOZGAN, IRAN. HORMOZGAN MEDICAL JOURNAL, 6(2), 1-6. SID. https://sid.ir/paper/60502/en

Vancouver: Copy

HADAEGH FARZAD, ZARE SH., TOUHIDI MARYAM, SAFA O., MAHOURI KH.. PITUITARY-THYROID AXIS FUNCTION AND CALCIUM-PHOSPHOR METABOLISM IN MAJOR THALASSEMIC PATIENTS, HORMOZGAN, IRAN. HORMOZGAN MEDICAL JOURNAL[Internet]. 2002;6(2):1-6. Available from: https://sid.ir/paper/60502/en

IEEE: Copy

FARZAD HADAEGH, SH. ZARE, MARYAM TOUHIDI, O. SAFA, and KH. MAHOURI, “PITUITARY-THYROID AXIS FUNCTION AND CALCIUM-PHOSPHOR METABOLISM IN MAJOR THALASSEMIC PATIENTS, HORMOZGAN, IRAN,” HORMOZGAN MEDICAL JOURNAL, vol. 6, no. 2, pp. 1–6, 2002, [Online]. Available: https://sid.ir/paper/60502/en

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