OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE

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MILADI GORJI H.; RASHIDIPOUR A.; VAFAEI A.A.; TAHERIAN ABAS ALI

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Journal: Hormozgan Medical Journal Year:2006 | Volume:10 | Issue:1 Page(s): 23-28

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Title

OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE

Author(s)

MILADI GORJI H. | RASHIDIPOUR A. | VAFAEI A.A. | TAHERIAN ABAS ALI | Issue Writer Certificate

Keywords

RECEPTORSQ4

OPIOIDQ3

RATSQ3

ANALGESICSQ4

MEDICINEQ4

HERBALQ4

Abstract

Melissa Officinalis (MO) overgrows in different parts of Iran. In previous studies, ethanol extract of aerial parts (leaf & stem) of MO showed anti-nconvulsant and sedative effects in RATS. This study was designed to evaluate anti-nociceptive effects in different doses of aqueous decoction extracts of MO and the role of OPIOID RECEPTORS in RATS.Methods: In this experimental study, 63 male mice (weighing 25-30g) in Tail Flick model were examined. Different doses of extract (5, 10, 25, 50 mg/kg IPMO) were injected to the separate groups and saline (10ml/kg-IP) was injected intrapeditoneal in control group. In four groups the role of OPIOID RECEPTORS (Naloxone 2mg.kg) was designed to evaluate anti-nociceptive effects in the aqueous decoction extracts of MO (5mg/kg) and 25 minutes after the injection the anti-nociceptive effect was evaluated. Analysis of variance was used to analysis the data.Results: The results showed that average time of Tail Flick had significant difference in two groups (P<0.0001) but the test groups had no significant difference in different doses. Based on the results, naloxone caused reduction in anti-nociceptive effects of 5 mg/kg Melissa Officinalis dose (P<0.0001).Conclusion: It is concluded that the aqueous extract of MO has anti-nociceptive activity which is not dose related, and is probably related to OPIOID RECEPTORS.Determination of other RECEPTORS which may have anti-nociceptive activity needs further investigation.

Cites

TO INVESTIGATE THE EFFECT OF PORTULACA OLERACEA L. AND MELISSA OFFICINALIS L. EXTRACT ON SLEEPING TIME IN MICE

References

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APA: Copy

MILADI GORJI, H., RASHIDIPOUR, A., VAFAEI, A.A., & TAHERIAN, ABAS ALI. (2006). OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE. HORMOZGAN MEDICAL JOURNAL, 10(1), 23-28. SID. https://sid.ir/paper/60692/en

Vancouver: Copy

MILADI GORJI H., RASHIDIPOUR A., VAFAEI A.A., TAHERIAN ABAS ALI. OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE. HORMOZGAN MEDICAL JOURNAL[Internet]. 2006;10(1):23-28. Available from: https://sid.ir/paper/60692/en

IEEE: Copy

H. MILADI GORJI, A. RASHIDIPOUR, A.A. VAFAEI, and ABAS ALI TAHERIAN, “OPIOID RECEPTORS ROLE ON ANTI-NOCICEPTIVE EFFECTS OF THE AQUEOUS EXTRACTS OF MELISSA OFFICINALIS IN MICE,” HORMOZGAN MEDICAL JOURNAL, vol. 10, no. 1, pp. 23–28, 2006, [Online]. Available: https://sid.ir/paper/60692/en

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