مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF CCKAR GENE POLYMORPHISM WITH GALLSTONE DISEASE

Pages

  86-91

Abstract

 Backgrounds and Objectives: Bile stagnation leads to cholesterol concentrates and Crystal formation that are GALL STONE precursors. Cholecystokinin kinase hormone receptor (CCKAR) role in contraction and depletion of gall bladder. POLYMORPHISMs of this receptor could have some role in gall bladder stone formation.Materials and Methods: Study on 116 gallstone cases and 118 healthy controls were performed. For molecular analysis, amplification of POLYMORPHISM containing sequence was obtained by polymerase chain reaction and then genotyping were carried out by restriction fragment length POLYMORPHISM. Finally statistical analysis had carried out for detection of association.Results: With case-control study we recognize that C/T genotype in rs1800857 POLYMORPHISM increases GALL STONE risk more than 3 times (P=0.035; OR=2.954; CI95%=1.072-8.14).Conclusion: This analysis confirms previous studies on rs1800857 POLYMORPHISM susceptibility to GALL STONE only in female and clarify the importance of this region to make a disease prediction.

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    APA: Copy

    MILANIZADEH, SAMAN, MOHAMADALIZADEH, AMIRHOOSHANG, AZIMZADEH, PEDRAM, ROMANI, SARA, KHANYAGHMA, MAHSA, MOHEBBI, SEYED REZA, ZALI, MOHAMMADREZA, & ROSHANI, MOHAMMAD. (2013). ASSOCIATION OF CCKAR GENE POLYMORPHISM WITH GALLSTONE DISEASE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(1), 86-91. SID. https://sid.ir/paper/608752/en

    Vancouver: Copy

    MILANIZADEH SAMAN, MOHAMADALIZADEH AMIRHOOSHANG, AZIMZADEH PEDRAM, ROMANI SARA, KHANYAGHMA MAHSA, MOHEBBI SEYED REZA, ZALI MOHAMMADREZA, ROSHANI MOHAMMAD. ASSOCIATION OF CCKAR GENE POLYMORPHISM WITH GALLSTONE DISEASE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;35(1):86-91. Available from: https://sid.ir/paper/608752/en

    IEEE: Copy

    SAMAN MILANIZADEH, AMIRHOOSHANG MOHAMADALIZADEH, PEDRAM AZIMZADEH, SARA ROMANI, MAHSA KHANYAGHMA, SEYED REZA MOHEBBI, MOHAMMADREZA ZALI, and MOHAMMAD ROSHANI, “ASSOCIATION OF CCKAR GENE POLYMORPHISM WITH GALLSTONE DISEASE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 1, pp. 86–91, 2013, [Online]. Available: https://sid.ir/paper/608752/en

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