مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

RELATIONSHIP BETWEEN PATIENT DEMOGRAPHIC CHARACTERISTICS, VALPROIC ACID DOSAGE AND CLEARANCE IN ADULT IRANIAN PATIENTS

Pages

  702-708

Abstract

 Objective(s): As there are conflicting findings regarding the CLEARANCE-dose and patient characteristics relationships for VALPROIC ACID (VPA), this study was conducted to investigate the relationship between patient DEMOGRAPHIC CHARACTERISTICs, VPA dosage and the drug CLEARANCE in adult Iranian patients.Materials and Methods: Patients (N=47) were either on monotherapy with VPA or were under co-treatment with drugs that have no effect on VPA PHARMACOKINETIC (PK) profile. All of the patients received VPA at therapeutic dose. Steady state trough plasma concentrations of VPA were determined by Fluorescence Polarization Immunoassay (FPIA) and VPA apparent CLEARANCE (CL/F) were calculated in each patient.Results: Mean VPA dose and VPA CL/F were 8.93±2.2 mg/kg/day and 0.65±0.55 l/hr respectively. No significant correlations were found between VPA CL/F and patients' age, TBW and VPA dose. VPA CL/F values of male and female patients were compared and no significant difference between these two groups was noted (P>0.05). Significant correlation between VPA dose and total trough plasma concentration was found (P= 0.001). Mean total VPA plasma concentration was 54.51±23.74 mg/l.Conclusion: Our study showed PK of VPA was not affected by age, sex, TBW and VPA dose. However, for detailed results and construction of VPA PK model in Iranian patients, it is necessary to evaluate VPA PK in a larger sample size with different VPA doses, age and TBW ranges.

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    APA: Copy

    AGHEBATI, TAMARA, FOROUGHIPOUR, MOHSEN, AZARPAZHOOH, MAHMOUD REZA, MOKHBER, NAGHMEH, HASANZADEH KHAYAT, MOHAMMAD, VAHDATI, NASER, & MOHAMMADPOUR, AMIR HOOSHANG. (2012). RELATIONSHIP BETWEEN PATIENT DEMOGRAPHIC CHARACTERISTICS, VALPROIC ACID DOSAGE AND CLEARANCE IN ADULT IRANIAN PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 15(2), 702-708. SID. https://sid.ir/paper/611615/en

    Vancouver: Copy

    AGHEBATI TAMARA, FOROUGHIPOUR MOHSEN, AZARPAZHOOH MAHMOUD REZA, MOKHBER NAGHMEH, HASANZADEH KHAYAT MOHAMMAD, VAHDATI NASER, MOHAMMADPOUR AMIR HOOSHANG. RELATIONSHIP BETWEEN PATIENT DEMOGRAPHIC CHARACTERISTICS, VALPROIC ACID DOSAGE AND CLEARANCE IN ADULT IRANIAN PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2012;15(2):702-708. Available from: https://sid.ir/paper/611615/en

    IEEE: Copy

    TAMARA AGHEBATI, MOHSEN FOROUGHIPOUR, MAHMOUD REZA AZARPAZHOOH, NAGHMEH MOKHBER, MOHAMMAD HASANZADEH KHAYAT, NASER VAHDATI, and AMIR HOOSHANG MOHAMMADPOUR, “RELATIONSHIP BETWEEN PATIENT DEMOGRAPHIC CHARACTERISTICS, VALPROIC ACID DOSAGE AND CLEARANCE IN ADULT IRANIAN PATIENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 15, no. 2, pp. 702–708, 2012, [Online]. Available: https://sid.ir/paper/611615/en

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