EFFECT OF BERBERINE HYDROCHLORIDE AND VITAMIN E ON LEARNING AND MEMORY IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS

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KALALIAN MOGHADDAM H.; VAEZI GH.; MESRIPOUR ALAVIJEH M.; SALIMI M.; GHANBARI F.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2015 | Volume:22 | Issue:95 Page(s): 46-58

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Title

EFFECT OF BERBERINE HYDROCHLORIDE AND VITAMIN E ON LEARNING AND MEMORY IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS

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Keywords

DIABETES MELLITUSQ2

BERBERINE HYDROCHLORIDEQ2

VITAMIN EQ2

SPATIAL RECOGNITIONQ2

OBJECTIVE RECOGNITIONQ2

Abstract

Background and Objective: Increasing evidence has shown that diabetes induces cognitive dysfunction and impairs learning and memory. Berberine is an isoquinoline alkaloid and VITAMIN E is a fat-soluble antioxidant with multiple pharmacological effects on diabetes. Thus, we investigated the effect of BERBERINE HYDROCHLORIDE and VITAMIN E on diabetes-induced cognitive dysfunction in rats.Materials and Methods: 48 male Wistar rats were randomly selected and allocated in 6 control groups: control treated with VITAMIN E (30mg/kg), diabetic and Berberine-treated diabetic group (100mg/kg), VITAMIN E-treated diabetic group (30mg/kg) and a diabetic group treated with both VITAMIN E and Berbrine. Diabetes was induced by STZ administration at dose of 55mg/kg through Intraperitoneal injection route. BERBERINE HYDROCHLORIDE and VITAMIN E were administered per os, respectively at doses of 100 and 30 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including SPATIAL RECOGNITION and OBJECTIVE RECOGNITION were performed at the end of the study.Results: Diabetic group treated with both drugs demonstrated significant behavioral differences as compared to diabetic, VITAMIN E-treated diabetic (30mg/kg), and Berberine -treated diabetic (100mg/kg) groups. In the meantime, cognitive test value demonstrated an increase in this group.Conclusion: BERBERINE HYDROCHLORIDE and VITAMIN E administration for 6 weeks improve cognitive dysfunction in streptozotocin -induced diabetes in rats.

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APA: Copy

KALALIAN MOGHADDAM, H., VAEZI, GH., MESRIPOUR ALAVIJEH, M., SALIMI, M., & GHANBARI, F.. (2015). EFFECT OF BERBERINE HYDROCHLORIDE AND VITAMIN E ON LEARNING AND MEMORY IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 22(95), 46-58. SID. https://sid.ir/paper/61211/en

Vancouver: Copy

KALALIAN MOGHADDAM H., VAEZI GH., MESRIPOUR ALAVIJEH M., SALIMI M., GHANBARI F.. EFFECT OF BERBERINE HYDROCHLORIDE AND VITAMIN E ON LEARNING AND MEMORY IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2015;22(95):46-58. Available from: https://sid.ir/paper/61211/en

IEEE: Copy

H. KALALIAN MOGHADDAM, GH. VAEZI, M. MESRIPOUR ALAVIJEH, M. SALIMI, and F. GHANBARI, “EFFECT OF BERBERINE HYDROCHLORIDE AND VITAMIN E ON LEARNING AND MEMORY IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 22, no. 95, pp. 46–58, 2015, [Online]. Available: https://sid.ir/paper/61211/en

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