THE EFFECT OF BERBERINE HYDROCHLORIDE ON MOTOR FUNCTION IMPAIRMENT IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

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MESRIPOUR ALAVIJEH MAHNAZ; KALALIAN MOGHADDAM HAMID; VAEZI GHOLAMHASAN

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Journal: KNOWLEDGE AND HEALTH Year:2014 | Volume:8 | Issue:4 Page(s): 181-186

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Title

THE EFFECT OF BERBERINE HYDROCHLORIDE ON MOTOR FUNCTION IMPAIRMENT IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

Author(s)

MESRIPOUR ALAVIJEH MAHNAZ | KALALIAN MOGHADDAM HAMID | VAEZI GHOLAMHASAN | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

BERBERINE HYDROCHLORIDEQ3

MOTOR FUNCTIONQ3

Y MAZEQ3

INCLEND PLANEQ3

BARFIXQ3

Abstract

Introduction: Ddiabetes induce MOTOR FUNCTION impairment. Berberine is an isoquinoline alkaloid that has multiple pharmacological effects including anti-diabetic and antioxidant activity.Methods: 40 male wistar rats were randomly selected and allocated to 5 equal groups: Control, Control berberine-treated (100 mg/kg), diabetic, and berberine- treated diabetic (50, 100 mg/kg). Diabetes was induced by STZ administration at the dose of 55 mg/ kg through i.p. route. BERBERINE HYDROCHLORIDE was administered p.o. at doses of 50 and 100 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein in 1, 3, 5, and 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including Y MAZE task, INCLEND PLANE and BARFIX were performed at the end of 6th and 7th weeks.Results: diabetic Berberine-treated groups (50, 100 mg/kg/day) has significant improvement rather than diabetic group in INCLEND PLANE test and Y MAZE task. Conclusion: BERBERINE HYDROCHLORIDE administration for 6 weeks improves MOTOR FUNCTION impairment in streptozotocin- induced diabetic rats.

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APA: Copy

MESRIPOUR ALAVIJEH, MAHNAZ, KALALIAN MOGHADDAM, HAMID, & VAEZI, GHOLAMHASAN. (2014). THE EFFECT OF BERBERINE HYDROCHLORIDE ON MOTOR FUNCTION IMPAIRMENT IN STREPTOZOTOCIN- INDUCED DIABETIC RATS. KNOWLEDGE AND HEALTH, 8(4), 181-186. SID. https://sid.ir/paper/108084/en

Vancouver: Copy

MESRIPOUR ALAVIJEH MAHNAZ, KALALIAN MOGHADDAM HAMID, VAEZI GHOLAMHASAN. THE EFFECT OF BERBERINE HYDROCHLORIDE ON MOTOR FUNCTION IMPAIRMENT IN STREPTOZOTOCIN- INDUCED DIABETIC RATS. KNOWLEDGE AND HEALTH[Internet]. 2014;8(4):181-186. Available from: https://sid.ir/paper/108084/en

IEEE: Copy

MAHNAZ MESRIPOUR ALAVIJEH, HAMID KALALIAN MOGHADDAM, and GHOLAMHASAN VAEZI, “THE EFFECT OF BERBERINE HYDROCHLORIDE ON MOTOR FUNCTION IMPAIRMENT IN STREPTOZOTOCIN- INDUCED DIABETIC RATS,” KNOWLEDGE AND HEALTH, vol. 8, no. 4, pp. 181–186, 2014, [Online]. Available: https://sid.ir/paper/108084/en

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