THE EFFECT OF ELAEAGNUS ANGUSTIFOLIA WATER EXTRACT ON SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN RATS

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TAMTAJI O.R.; TAGHIZADEH M.; TAKHTFIROOZEH S.M.; TALAEI S.A.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2015 | Volume:22 | Issue:95 Page(s): 101-111

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Title

THE EFFECT OF ELAEAGNUS ANGUSTIFOLIA WATER EXTRACT ON SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN RATS

Author(s)

TAMTAJI O.R. | TAGHIZADEH M. | TAKHTFIROOZEH S.M. | TALAEI S.A. | Issue Writer Certificate

Keywords

ELAEAGNUS ANGUSTIFOLIAQ2

MEMORYQ2

SCOPOLAMINEQ1

MORRIS WATER MAZEQ2

RATSQ2

Abstract

Background and Objective: Impaired cognitive function and MEMORY, a characteristic of Alzheimer' s disease, can be caused by decreased activity of the cholinergic system. SCOPOLAMINE, a muscarinic receptor antagonist, may cause temporary impairment in MEMORY and provide an Alzheimer's disease model. This study was designed to evaluate the effects of water extract ofELAEAGNUS ANGUSTIFOLIA on MEMORY impairment caused by SCOPOLAMINE.Materials and Methods: Sixthy male Wistar RATS were randomly assigned to 6 groups (n=10 for each group).Four groups received SCOPOLAMINE (1mg/kg, IP) and water extract ofELAEAGNUS ANGUSTIFOLIA (50, 100, 200 and 400 mg/kg) along with a positive control group (received SCOPOLAMINE) and a negative control group.Water extract ofELAEAGNUS ANGUSTIFOLIA was administered through gavage every day for 4 weeks. Using MORRIS WATER MAZE (MWM), spatial learning and MEMORY were evaluated.Results: The present study showed that SCOPOLAMINE injection leads to impairment of learning and MEMORY of RATS in the Morris water test (P<0.0001). In addition, ELAEAGNUS ANGUSTIFOLIA water extracts dosedependently improved the learning and MEMORY impairment induced by SCOPOLAMINE in RATS (P<0.0001).There was no significant difference between groups that received water extract ofELAEAGNUS ANGUSTIFOLIA and negative control group (P=1).Conclusion: Water extract of ELAEAGNUS ANGUSTIFOLIA improves spatial learning and MEMORY induced by SCOPOLAMINE in RATS.

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APA: Copy

TAMTAJI, O.R., TAGHIZADEH, M., TAKHTFIROOZEH, S.M., & TALAEI, S.A.. (2015). THE EFFECT OF ELAEAGNUS ANGUSTIFOLIA WATER EXTRACT ON SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 22(95), 101-111. SID. https://sid.ir/paper/61212/en

Vancouver: Copy

TAMTAJI O.R., TAGHIZADEH M., TAKHTFIROOZEH S.M., TALAEI S.A.. THE EFFECT OF ELAEAGNUS ANGUSTIFOLIA WATER EXTRACT ON SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2015;22(95):101-111. Available from: https://sid.ir/paper/61212/en

IEEE: Copy

O.R. TAMTAJI, M. TAGHIZADEH, S.M. TAKHTFIROOZEH, and S.A. TALAEI, “THE EFFECT OF ELAEAGNUS ANGUSTIFOLIA WATER EXTRACT ON SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN RATS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 22, no. 95, pp. 101–111, 2015, [Online]. Available: https://sid.ir/paper/61212/en

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