ASSOCIATION OF DD GENOTYPE OF INSERTION/DELETION POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND LUPUS NEPHROPATHY

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SALIMI SAEEDEH; NAGHAVI ANOOSH; ZAKERI ZAHRA; NABIZADEH SIMA; FARAJIAN MASHHADI FARZANEH; SANDOUGHI MAHNAZ

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Journal: Zahedan Journal of Research in Medical Sciences Year:2013 | Volume:15 | Issue:10 Page(s): 69-73

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Title

ASSOCIATION OF DD GENOTYPE OF INSERTION/DELETION POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND LUPUS NEPHROPATHY

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SYSTEMIC LUPUS ERYTHEMATOSUS LUPUS NEPHROPATHY ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM IRAN

Abstract

Background: Systemic lupus erythematosus (SLE) is a multisystem disease with unknown etiology. We hypothesized that insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene may influence the development and/or progression of SLE and lupus nephritis.Materials and Methods: In a crass sectional case-control study, genomic DNA from 106 SLE patients and 103 healthy controls matched for sex, age, and ethnicity, were genotyped for the (I/D) polymorphism of ACE gene by polymerase chain reaction (PCR). Comparison of quantitative variants between two groups was assessed by student t-test and association between qualitative variables was analyzed by the chi-square or Fisher exact tests.Results: The frequency of DD genotype in SLE patients was significantly higher than control group (25.5 % vs.14 %), and the risk of SLE was 2.2 times greater in subjects with DD genotype than the individual by DI and II genotypes (OR, 2.2 [95% CI, 1.1 to 4.4]; p=0.023). The distribution of D allele in SLE patients was significantly higher (p=0.021) compare to controls (47 and 36.4, respectively). The Risk of nephropathy in SLE patients with DD genotype was three times more than other genotypes (OR), 3 [95% CI, 1.1 to 8]; p=0.027].Conclusion: This study demonstrated that ACE DD genotype acts as a risk factor on SLE and Lupus nephropathy in an Iranian population.

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APA: Copy

SALIMI, SAEEDEH, NAGHAVI, ANOOSH, ZAKERI, ZAHRA, NABIZADEH, SIMA, FARAJIAN MASHHADI, FARZANEH, & SANDOUGHI, MAHNAZ. (2013). ASSOCIATION OF DD GENOTYPE OF INSERTION/DELETION POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND LUPUS NEPHROPATHY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(10), 69-73. SID. https://sid.ir/paper/612833/en

Vancouver: Copy

SALIMI SAEEDEH, NAGHAVI ANOOSH, ZAKERI ZAHRA, NABIZADEH SIMA, FARAJIAN MASHHADI FARZANEH, SANDOUGHI MAHNAZ. ASSOCIATION OF DD GENOTYPE OF INSERTION/DELETION POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND LUPUS NEPHROPATHY. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(10):69-73. Available from: https://sid.ir/paper/612833/en

IEEE: Copy

SAEEDEH SALIMI, ANOOSH NAGHAVI, ZAHRA ZAKERI, SIMA NABIZADEH, FARZANEH FARAJIAN MASHHADI, and MAHNAZ SANDOUGHI, “ASSOCIATION OF DD GENOTYPE OF INSERTION/DELETION POLYMORPHISM OF ANGIOTENSIN-CONVERTING ENZYME GENE WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND LUPUS NEPHROPATHY,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 10, pp. 69–73, 2013, [Online]. Available: https://sid.ir/paper/612833/en

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