THE IMPLEMENTATION OF EIGHT WEEKS OF ENDURANCE TRAINING AND CHLORIDE ADMINISTRATION ON BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM LEVELS IN RATS WITH ALZHEIMER’S DISEASE

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ZARE M.; ZAR A.; EDALATMANESH M.A.

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Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2016 | Volume:24 | Issue:103 Page(s): 62-70

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Title

THE IMPLEMENTATION OF EIGHT WEEKS OF ENDURANCE TRAINING AND CHLORIDE ADMINISTRATION ON BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM LEVELS IN RATS WITH ALZHEIMER’S DISEASE

Author(s)

ZARE M. | ZAR A. | EDALATMANESH M.A. | Issue Writer Certificate

Keywords

ALZHEIMER DISEASEQ1

EXERCISEQ1

LITHIUM CHLORIDEQ1

BRAIN-DERIVED NEUROTROPHIC FACTORQ1

RATSQ2

Abstract

Background and Objective: Alzheimer is a neurodegenerative disease in which a reduced memory capacity and numerous changes occur in the patients brain. This study was embarked to shed light on the effects of eight weeks of endurance training and chloride administration on BRAIN-DERIVED NEUROTROPHIC FACTOR serum levels in female RATS with Alzheimer’s disease.Materials and Methods: 70 female Sperag Dawley RATS were randomly divided into seven groups including: 1.control, 2. Sham, 3. LITHIUM CHLORIDE 20, 4. LITHIUM CHLORIDE 40, 5. Endurance training, 6. Endurance training LITHIUM CHLORIDE 20, 7. Endurance training and LITHIUM CHLORIDE 40. Alziemer was induced in RATS by methyl chloride. Groups of endurance training, endurance training plus lithium coloride 20 and endurance training plus LITHIUM CHLORIDE 40 ran on a treadmill with no incline at the speed of 15 to 20 meters per minute for 15 to 30 minutes each session and five times for eight weeks. The groups of lithium coloride 20, endurance training and lithium coloride 20 received lithium coloride 20 mg/kg according to their body weight per day. The lithium coloride 40, endurance training and lithium coloride 40 received lithium coloride 40 mg/kg of their body weight per day for 14 days. During this period, the control group did not have any activity and did not recieve any treatment. ANOVA and tukey post hoc tests were used for statistical analysis.Results: The results showed that chloride as well as endurance training along with their interactive effects increased levels of BRAIN-DERIVED NEUROTROPHIC FACTOR poisoning by neurotoxins. But the greatest impact was observed in endurance training and chloride 20. Also, serum levels of BRAIN-DERIVED NEUROTROPHIC FACTOR significantly decresed owing to Methyltin poisoning in female RATS (p<0.05).Conclusion: Based on these findings, we conclude that chloride, endurance training and their interactive effects in female RATS with Alzheimer’s disease raised BRAIN-DERIVED NEUROTROPHIC FACTOR serum levels which implies that Alzheimer’s disease can be improved.

Cites

EFFECT OF ALOEVERA WITH SWIMMING TRAINING ON THE ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE LEVELS OF DIABETIC RATS

References

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Cite

APA: Copy

ZARE, M., ZAR, A., & EDALATMANESH, M.A.. (2016). THE IMPLEMENTATION OF EIGHT WEEKS OF ENDURANCE TRAINING AND CHLORIDE ADMINISTRATION ON BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM LEVELS IN RATS WITH ALZHEIMER’S DISEASE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 24(103), 62-70. SID. https://sid.ir/paper/61294/en

Vancouver: Copy

ZARE M., ZAR A., EDALATMANESH M.A.. THE IMPLEMENTATION OF EIGHT WEEKS OF ENDURANCE TRAINING AND CHLORIDE ADMINISTRATION ON BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM LEVELS IN RATS WITH ALZHEIMER’S DISEASE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2016;24(103):62-70. Available from: https://sid.ir/paper/61294/en

IEEE: Copy

M. ZARE, A. ZAR, and M.A. EDALATMANESH, “THE IMPLEMENTATION OF EIGHT WEEKS OF ENDURANCE TRAINING AND CHLORIDE ADMINISTRATION ON BRAIN- DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM LEVELS IN RATS WITH ALZHEIMER’S DISEASE,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 24, no. 103, pp. 62–70, 2016, [Online]. Available: https://sid.ir/paper/61294/en

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