THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS

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ESMAEILI M.H.; GANJKHANI M.; MELATI A.A.; RASTAK SH.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2007 | Volume:15 | Issue:59 Page(s): 9-20

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Title

THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS

Author(s)

ESMAEILI M.H. | GANJKHANI M. | MELATI A.A. | RASTAK SH. | Issue Writer Certificate

Keywords

MORPHINE-WITHDRAWAL SYNDROMEQ3

LOCUS COERULEUSQ2

SELF-ADMINISTRATIONQ3

RATQ2

Abstract

Background and Objective: LOCUS COERULEUS (LC) has been hypothesized to play an important role in a variety of behaviors and opiate withdrawal. This study was designed to determine the effects of reversible inactivation of LC on SELF-ADMINISTRATION of morphine and morphine- withdrawal syndrome signs (MWS).Materials and Methods: 24 male RATs (250-300gr) were surgically implanted bilaterally with cannula in LC then implanted with catheters in the right jugular vein. The RATs were tested in 2 groups:Control (saline) and morphine. Morphine group was divided into 3 subgroups: control, sham-operated and LC-inactivated group where they received 1mL 2% Lidocaine 5 minutes prior to testing. Animals were allowed to self-administer morphine (1mg/infusion) during 10 consecutive days for 2 hours. The number of lever pressing was recorded. At the end of the training day all groups received naloxone (2mg/kg I.P) and MWS were studied for 30 minutes.Results: LC inactivation prevents the development of tolerance and dependence on morphine and greatly attenuates MORPHINE-WITHDRAWAL SYNDROME.Conclusion: LC inactivation not only attenuates morphine withdrawal syndrome but also prevents morphine tolerance and dependence in RATs.

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APA: Copy

ESMAEILI, M.H., GANJKHANI, M., MELATI, A.A., & RASTAK, SH.. (2007). THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 15(59), 9-20. SID. https://sid.ir/paper/61410/en

Vancouver: Copy

ESMAEILI M.H., GANJKHANI M., MELATI A.A., RASTAK SH.. THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2007;15(59):9-20. Available from: https://sid.ir/paper/61410/en

IEEE: Copy

M.H. ESMAEILI, M. GANJKHANI, A.A. MELATI, and SH. RASTAK, “THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 15, no. 59, pp. 9–20, 2007, [Online]. Available: https://sid.ir/paper/61410/en

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