ANTI-APOPTOTIC EFFECT OF SELEGILINE AS MONOAMINE OXIDASE INHIBITOR ON RAT HIPPOCAMPUS DERIVED NEURAL STEM CELLS IN OXIDATIVE STRESS CONDITION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKFAR A.; ABDANIPOUR A.R.; GHOLINEJAD M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2017 | Volume:25 | Issue:111 Page(s): 41-56

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

821

Download:

Cites:

Information Journal Paper

Title

ANTI-APOPTOTIC EFFECT OF SELEGILINE AS MONOAMINE OXIDASE INHIBITOR ON RAT HIPPOCAMPUS DERIVED NEURAL STEM CELLS IN OXIDATIVE STRESS CONDITION

Author(s)

NIKFAR A. | ABDANIPOUR A.R. | GHOLINEJAD M. | Issue Writer Certificate

Keywords

NEURAL STEM CELLSQ1

SELEGILINEQ1

OXIDATIVE STRESSQ1

APOPTOSISQ2

Abstract

Background and Objective: Damaged and inflammatory cells in the nervous system produce reactive oxygen species (ROS). The overproduction of ROS can cause serious damage to important biomolecules and over activation of programmed cell death leads to many progressive neurodegenerative disorders. The aim of this study was to evaluate the effects of SELEGILINE on inhibition of APOPTOSIS in oxidative damage induced by hydrogen peroxide in rat hippocampus derived NEURAL STEM CELLS.Materials and Methods: The NEURAL STEM CELLS were isolated from the hippocampi of neonatal rats then pretreated with different doses of SELEGILINE for 48 hours while later being exposed to 125mM H2O2 for 30 min. Using MTT assay and TUNEL staining, we evaluated the effects of SELEGILINE on cell survival and APOPTOSIS in pretreated NSCs compared to control groups. Also, the induction of NSCs to neuron-like cells was evaluated using Nissl staining.Results: The results showed that APOPTOSIS rate was significantly decreased in 10-7 M of SELEGILINE pretreated NSCs compared to the control group. Also, the mean percentage of Nissl positive cells significantly increased in SELEGILINE pretreated NEURAL STEM CELLS compared to the control group.Conclusion: Our findings suggest that SELEGILINE protects NSCs against OXIDATIVE STRESS induced cell death, and therefore, it may be used to promote the survival rate of NSCs and can be a candidate for treatment of OXIDATIVE STRESS-mediated neurological diseases.

Cites

No record.

References

Cite

APA: Copy

NIKFAR, A., ABDANIPOUR, A.R., & GHOLINEJAD, M.. (2017). ANTI-APOPTOTIC EFFECT OF SELEGILINE AS MONOAMINE OXIDASE INHIBITOR ON RAT HIPPOCAMPUS DERIVED NEURAL STEM CELLS IN OXIDATIVE STRESS CONDITION. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 25(111), 41-56. SID. https://sid.ir/paper/61580/en

Vancouver: Copy

NIKFAR A., ABDANIPOUR A.R., GHOLINEJAD M.. ANTI-APOPTOTIC EFFECT OF SELEGILINE AS MONOAMINE OXIDASE INHIBITOR ON RAT HIPPOCAMPUS DERIVED NEURAL STEM CELLS IN OXIDATIVE STRESS CONDITION. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2017;25(111):41-56. Available from: https://sid.ir/paper/61580/en

IEEE: Copy

A. NIKFAR, A.R. ABDANIPOUR, and M. GHOLINEJAD, “ANTI-APOPTOTIC EFFECT OF SELEGILINE AS MONOAMINE OXIDASE INHIBITOR ON RAT HIPPOCAMPUS DERIVED NEURAL STEM CELLS IN OXIDATIVE STRESS CONDITION,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 25, no. 111, pp. 41–56, 2017, [Online]. Available: https://sid.ir/paper/61580/en

Related Journal Papers