THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHROKHABADI KH.; BAHARARA J.; ZAFAR BALANEJAD S.; HESAMI Z.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2014 | Volume:21 | Issue:88 Page(s): 1-11

Download Full-Text

Persian Verion

View:

1,464

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE

Author(s)

SHAHROKHABADI KH. | BAHARARA J. | ZAFAR BALANEJAD S. | HESAMI Z. | Issue Writer Certificate

Keywords

ATORVASTATINQ2

MCF7Q2

MTT ASSAYQ2

TUMOR CELLQ2

Abstract

Background and Objective: Due to progressive increase in the number of cases of cancer, there is a need to develop anti- tumor compounds. Statins have a variety of different effects on proliferation, migration and survival of cells and have been suggested as proper candidates for the inhibition of this disease. The aim of this study was to determine cytotoxicity effects of ATORVASTATIN with variety of concentrations on the growth of MCF7 cell line.Materials and Methods: MCF7 cell lines were incubated in RPMI 1640 medium supplemented with 10% FBS in a humidified incubator (37oC & 5% CO2). Different concentrations of ATORVASTATIN on quantitative proliferation of the cell line were determined by Dimethyl Thiazol Tetrazolium bromide (MTT) colorimetric assay and Trypan blue. The data were analyzed by SPSS version 11.5. The statistical analysis was performed by one-way ANOVA and Tukey's tests.Results: There was no statistical significance in cytotoxicity effect of 1 mmol and 0.1 mmol of ATORVASTATIN on survival of MCF7 cells after 24, 48 and 72 hrs comparing to control cells. But in 10 mmol concentration of ATORVASTATIN, a significant decrease was observed in survival of MCF7 cells at the mentioned time points.Conclusion: Different concentrations of ATORVASTATIN have different effects on the growth of cultured cell lines. It seems that 10µmol concentration decreases growth of cultured human breast cancer cells. Further animal studies on this subject are suggested.

Cites

CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652)

References

No record.

Cite

APA: Copy

SHAHROKHABADI, KH., BAHARARA, J., ZAFAR BALANEJAD, S., & HESAMI, Z.. (2014). THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 21(88), 1-11. SID. https://sid.ir/paper/61612/en

Vancouver: Copy

SHAHROKHABADI KH., BAHARARA J., ZAFAR BALANEJAD S., HESAMI Z.. THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2014;21(88):1-11. Available from: https://sid.ir/paper/61612/en

IEEE: Copy

KH. SHAHROKHABADI, J. BAHARARA, S. ZAFAR BALANEJAD, and Z. HESAMI, “THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 21, no. 88, pp. 1–11, 2014, [Online]. Available: https://sid.ir/paper/61612/en

Related Journal Papers