CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652)

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vaziri javid roya; MAGHSODI HOSSEIN; HAJIHOSSEINI REZA

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Journal: Research in Medicine Year:2017 | Volume:41 | Issue:2 Page(s): 97-111

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Title

CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652)

Author(s)

vaziri javid roya | MAGHSODI HOSSEIN | HAJIHOSSEINI REZA | Issue Writer Certificate

Keywords

CYTOTOXICQ2

CMLQ3

K562Q2

PUNICIC ACIDQ1

LEUKEMIAQ3

Abstract

Backgrond: Chronic myeloid LEUKEMIA (CML) is a malignant clonal disorder of hematopoietic stem cells that causes the increase of myeloid, erythroid cells, and blood platelets and hyperplasia in the bone marrow. This study is performed the effect of CYTOTOXICity of PUNICIC ACID of pomegranate seed oil on the cellular line of blood cancer (K652), as a model of Chronic Myeloid LEUKEMIA.Materials and Methods: In this experiential laboratory study. PUNICIC ACID of pomegranate seed oil was purchased from Clarodan Kerman Co., representative of LCG Co. in Iran. K562 cells were cultured and were administered with densities of 8 to 100 micrograms per milliliters (in 24h, 48h, and 72h). Cellular toxicity of PUNICIC ACID against K562 leukemic cells was estimated using the MTT, LDH and SDH method. Absorption was measured using Elisa machine. Then the data were analyzed with the computer software SPSS version 15.0 (SPSS Inc., Chicago, USA), t.test and ANOVA.Findings: PUNICIC ACID of pomegranate seed oil shows the most cellular toxicity effect at lc50=50 micrograms per milliliters and 72 hours after treatment. In other words, PUNICIC ACID of pomegranate seed oil expresses the effects of cellular toxicity on K562 cells, depending on the dosage.Conclusion: Considering the toxicity of PUNICIC ACID of pomegranate seed oil, PUNICIC ACID can be considered a potential candidate for further CML studies, and other cancer cells.

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References

THE EFFECT OF ATORVASTATIN ON PROGRESS AND PROLIFERATION OF MCF7 BREAST CANCER CELL LINE

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APA: Copy

vaziri javid, roya, MAGHSODI, HOSSEIN, & HAJIHOSSEINI, REZA. (2017). CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652). PAJOUHESH DAR PEZESHKI, 41(2 ), 97-111. SID. https://sid.ir/paper/41615/en

Vancouver: Copy

vaziri javid roya, MAGHSODI HOSSEIN, HAJIHOSSEINI REZA. CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652). PAJOUHESH DAR PEZESHKI[Internet]. 2017;41(2 ):97-111. Available from: https://sid.ir/paper/41615/en

IEEE: Copy

roya vaziri javid, HOSSEIN MAGHSODI, and REZA HAJIHOSSEINI, “CYTOTOXIC EFFECT OF PUNISIC ACID OF POMEGRANATE SEED OIL ON THE CELLULAR LINE OF BLOOD CANCER (K652),” PAJOUHESH DAR PEZESHKI, vol. 41, no. 2 , pp. 97–111, 2017, [Online]. Available: https://sid.ir/paper/41615/en

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