SYNERGISTIC EFFECT POLYMYXIN B SULPHATE AND TRIMETHOPRIM ON YERSINIA ENTEROCOLOTICA AND CLOSELY RELATED SPECIES

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SOLTAN DALLAL M.M.; HIDARZADEH S.; AZARSA M.; BAKHTIARI R.; SHARIFI YAZDI M.K.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2012 | Volume:20 | Issue:79 Page(s): 34-43

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Information Journal Paper

Title

SYNERGISTIC EFFECT POLYMYXIN B SULPHATE AND TRIMETHOPRIM ON YERSINIA ENTEROCOLOTICA AND CLOSELY RELATED SPECIES

Author(s)

Keywords

YERSINIA ENTEROCOLITICAQ2

SYNERGYSMQ2

POLYMYXIN B SULPHATEQ2

TRIMETHOPRIMQ2

Abstract

Background and Objectives: Previous studies have shown that polymyxin B sulfate and TRIMETHOPRIM antibiotics are not individually effective on YERSINIA ENTEROCOLITICA and their closely related species. The aim of this study was to evaluate the synergistic effect of above antibiotics on Y. enterocolitica and their closely related species, from the clinical and the natural environment specimen collected in Iran, and compare them with the isolates that that were obtained from the Pasteur institute collection in France.Materials and Methods: In total, 73 species from Iran and 25 from the Pasteur institute in France were tested. The microdilution method was used for the MIC according to the standard protocol.Results: The synergistic effect was seen in all tested samples. Growth received from 4.7% to 100% However, the human species from the Pasteur institute were more sensitive than the Iranian human and the environmental species were less sensitive than clinical specimens (1.6+16 mgr, 0.4+4 mgr in French Samples). The Y. enterocolitica isolates were less sensitive than the related species such as Y. intermedia, Y. fredriksenii, and Y. kristensenii.Conclusion: The synergistic effect of polymyxin B sulfate and trimthoprim were more evident on other closely related Yersinia species comparing to Y. enterocolitica.

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APA: Copy

SOLTAN DALLAL, M.M., HIDARZADEH, S., AZARSA, M., BAKHTIARI, R., & SHARIFI YAZDI, M.K.. (2012). SYNERGISTIC EFFECT POLYMYXIN B SULPHATE AND TRIMETHOPRIM ON YERSINIA ENTEROCOLOTICA AND CLOSELY RELATED SPECIES. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 20(79), 34-43. SID. https://sid.ir/paper/61640/en

Vancouver: Copy

SOLTAN DALLAL M.M., HIDARZADEH S., AZARSA M., BAKHTIARI R., SHARIFI YAZDI M.K.. SYNERGISTIC EFFECT POLYMYXIN B SULPHATE AND TRIMETHOPRIM ON YERSINIA ENTEROCOLOTICA AND CLOSELY RELATED SPECIES. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2012;20(79):34-43. Available from: https://sid.ir/paper/61640/en

IEEE: Copy

M.M. SOLTAN DALLAL, S. HIDARZADEH, M. AZARSA, R. BAKHTIARI, and M.K. SHARIFI YAZDI, “SYNERGISTIC EFFECT POLYMYXIN B SULPHATE AND TRIMETHOPRIM ON YERSINIA ENTEROCOLOTICA AND CLOSELY RELATED SPECIES,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 20, no. 79, pp. 34–43, 2012, [Online]. Available: https://sid.ir/paper/61640/en

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