THE EFFECT OF METRONIDAZOLE ON TESTICULAR TISSUES AND SPERMATOGENESIS OF ADULT MALE RATS

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SOHRABI D.; TAHERI SH.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Advances in Medical and Biomedical Research Year:2003 | Volume:11 | Issue:44 Page(s): 31-36

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Title

THE EFFECT OF METRONIDAZOLE ON TESTICULAR TISSUES AND SPERMATOGENESIS OF ADULT MALE RATS

Author(s)

SOHRABI D. | TAHERI SH. | Issue Writer Certificate

Keywords

METRONIDAZOLEQ2

SPERMATOGENESISQ2

TESTISESQ2

Abstract

Background: METRONIDAZOLE is an antibacterial medicine which is used for many years. This study was designed in Zanjan from 2001-2002 to detect side effects of this medication on SPERMATOGENESIS and testicular functions. Material and Methods: This experimental study was conducted on 24 male wistar rats which were divided into three groups: The control group who were receiving only pure water for 60 days; two experimental groups receiving 200 and 400 mg/kg/day METRONIDAZOLE for 60 days. Then the TESTISES of the rats were extruded and fixed in 10% Formalin and stained with Hematoxilin-Eosin methods. Results: The weight of the TESTISES and also the number of germinal cells were reduced significantly in the experimental groups (P<0.001). Reduction in the number of leydig cells were significant only in the rats which received 400 mg/kg METRONIDAZOLE per day (P<0.001). The changes in the number of sertoli cells were not significant in all groups. Conclusions: METRONIDAZOLE may affect testicular tissue and reduce its function. Thus, it is recommended to be used cautiously, especially in males.

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APA: Copy

SOHRABI, D., & TAHERI, SH.. (2003). THE EFFECT OF METRONIDAZOLE ON TESTICULAR TISSUES AND SPERMATOGENESIS OF ADULT MALE RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 11(44), 31-36. SID. https://sid.ir/paper/61650/en

Vancouver: Copy

SOHRABI D., TAHERI SH.. THE EFFECT OF METRONIDAZOLE ON TESTICULAR TISSUES AND SPERMATOGENESIS OF ADULT MALE RATS. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2003;11(44):31-36. Available from: https://sid.ir/paper/61650/en

IEEE: Copy

D. SOHRABI, and SH. TAHERI, “THE EFFECT OF METRONIDAZOLE ON TESTICULAR TISSUES AND SPERMATOGENESIS OF ADULT MALE RATS,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 11, no. 44, pp. 31–36, 2003, [Online]. Available: https://sid.ir/paper/61650/en

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