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Information Journal Paper

Title

EFFECT OF ERYTHROMYCIN ON ALBENDAZOLE-INDUCED TERATOGENICITY IN PREGNANT RATS

Pages

  43-46

Abstract

 Background: ALBENDAZOLE is utilized as an anthelmentic agent. One its side effect is TERATOGENICITY. This effect apparently is related to its metabolites especially ALBENDAZOLE sulfoxid. The aim of present study was evaluation effect of ERYTHROMYCIN (as enzyme inhibitor in biotransformation) on ALBENDAZOLE biotransformation and consequently fetal malformation.Materials and Methods: Four groups of female pregnant wistar RATS (8 RATS each group) were used. First group received normal saline (as control group). A single oral dose 30 mg/kg of ALBENDAZOLE was administered to RATS on day 10 of gestation in group 2. RATS in group 3 received ALBENDAZOLE similar group 2 and ERYTHROMYCIN at dose 60 mg/kg. RATS in group 4 received only ERYTHROMYCIN on day 10 of gestation. The RATS were euthanatized on day 20 of gestation. The skeletal malformation of fetus was studied by stereomicroscope after staining by Alizarin red-Alcian blue.Results: The length and weight of fetuses were significantly decreased by ALBENDAZOLE but ERYTHROMYCIN did not prevent this effect. In group that received only ERYTHROMYCIN, the length and weight of fetuses was similar to control group. ERYTHROMYCIN decreased ALBENDAZOLE effect on weight of placenta. There was an increase in resorption by ERYTHROMYCIN when co-administrated with ALBENDAZOLE. The incidence of skeletal malformations (mostly of the limbs, vertebrae and palate) decreased significantly by ERYTHROMYCIN when co-administrated with ALBENDAZOLE.Conclusion: Thus, ERYTHROMYCIN may inhibit ALBENDAZOLE biotransformation and decrease TERATOGENICITY of it metabolites, but this subject needs more detailed evaluation.

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    APA: Copy

    RANJBAR, REZA, NAJAFZADEH, HOSSEIN, MOROVVATI, HASSAN, KHAKSARY MAHABADY, MAHMOOD, & LAK, ELNAZ. (2013). EFFECT OF ERYTHROMYCIN ON ALBENDAZOLE-INDUCED TERATOGENICITY IN PREGNANT RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(5), 43-46. SID. https://sid.ir/paper/616517/en

    Vancouver: Copy

    RANJBAR REZA, NAJAFZADEH HOSSEIN, MOROVVATI HASSAN, KHAKSARY MAHABADY MAHMOOD, LAK ELNAZ. EFFECT OF ERYTHROMYCIN ON ALBENDAZOLE-INDUCED TERATOGENICITY IN PREGNANT RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(5):43-46. Available from: https://sid.ir/paper/616517/en

    IEEE: Copy

    REZA RANJBAR, HOSSEIN NAJAFZADEH, HASSAN MOROVVATI, MAHMOOD KHAKSARY MAHABADY, and ELNAZ LAK, “EFFECT OF ERYTHROMYCIN ON ALBENDAZOLE-INDUCED TERATOGENICITY IN PREGNANT RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 5, pp. 43–46, 2013, [Online]. Available: https://sid.ir/paper/616517/en

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