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Title

SERUM LEVELS OF IL-17, IL-4, AND INFγ IN SERBIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS

Pages

  18-22

Abstract

 Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. There are controversial data about the profile of interleukin-17 (IL-17A), interleukin-4 (IL-4), and interferon-gamma (INFg), indicating in some studies the key role of IL-17, while in others the Th1 cytokines.Materials and Methods: Serum samples of 31 early RA patients were evaluated for erythrocytes sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibodies (anti-CCP), and for the tested cytokines (IL-17A, IL-4, and INFg). Disease activity score (DAS28) calculation was done for all patients. Control serum samples were obtained from 29 healthy volunteers.Results: The levels of tested cytokines were significantly higher (IL-17A, p<0.001, INFg, p<0.001, IL-4, p<0.01) in patients with early RA, compared to the healthy controls. In early RA patients, a strong correlation of serum IL-17A was found with DAS28, ESR, and CRP.Also, significant negative correlation was found between serum INFg levels and the DAS28 score, indicating that INFg may play a key role in maintaining immune homeostasis in patients with RA.Conclusion: The mean serum IL-17A levels in patients with early RA, corresponded with the disease activity and severity. This might highlight the usefulness of the serum IL-17A level in defining the activity and predictive patterns, for aggressive disease therapy, and it might express specific therapeutically targets.

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    APA: Copy

    PAVLOVIC, VOJA, DIMIC, ALEKSANDAR, MILENKOVIC, SASA, & KRTINIC, DANE. (2014). SERUM LEVELS OF IL-17, IL-4, AND INFγ IN SERBIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 18(1), 18-22. SID. https://sid.ir/paper/618162/en

    Vancouver: Copy

    PAVLOVIC VOJA, DIMIC ALEKSANDAR, MILENKOVIC SASA, KRTINIC DANE. SERUM LEVELS OF IL-17, IL-4, AND INFγ IN SERBIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;18(1):18-22. Available from: https://sid.ir/paper/618162/en

    IEEE: Copy

    VOJA PAVLOVIC, ALEKSANDAR DIMIC, SASA MILENKOVIC, and DANE KRTINIC, “SERUM LEVELS OF IL-17, IL-4, AND INFγ IN SERBIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 18, no. 1, pp. 18–22, 2014, [Online]. Available: https://sid.ir/paper/618162/en

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