ASSOCIATION STUDY BETWEEN BAT 1 GENE VARIATION AND LATE-ONSET (SPORADIC) ALZHEIMER’S DISEASE IN IRANIAN POPULATION

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SOOSANABADI FARAHANI M.; KAMALI K.; KARIMLOU M.; BANAN M.; KHORRAM KHORSHID H.R.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:6 (75) Page(s): 66-71

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Title

ASSOCIATION STUDY BETWEEN BAT 1 GENE VARIATION AND LATE-ONSET (SPORADIC) ALZHEIMER’S DISEASE IN IRANIAN POPULATION

Author(s)

Keywords

ALZHEIMER DISEASE

GENETIC ASSOCIATION STUDIES

BAT1

INFLAMMATION

POLYMORPHISM

Abstract

Background: There are evidences indicating that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with Alzheimer’s disease (AD) pathology. In the current study BAT1-22 promoter POLYMORPHISM was analyzed in AD and control subjects.Materials and Methods: In this case-control study, genomic DNA from peripheral blood samples of 153 Alzheimer’s patients and 153 healthy controls was extracted using salting-out method. DNA analysis was performed by PCR-RFLP method and p<0.05 was considered statistically significant.Results: After genotyping and statistical analysis the results failed to show any association between BAT1-22 promoter POLYMORPHISM and sporadic Alzheimer’s disease.Conclusion: BAT1-22 is not associated with Alzheimer’s disease in Iranian population and so has no effect on predisposition to sporadic Alzheimer’s disease.

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APA: Copy

SOOSANABADI FARAHANI, M., KAMALI, K., KARIMLOU, M., BANAN, M., & KHORRAM KHORSHID, H.R.. (2013). ASSOCIATION STUDY BETWEEN BAT 1 GENE VARIATION AND LATE-ONSET (SPORADIC) ALZHEIMER’S DISEASE IN IRANIAN POPULATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(6 (75)), 66-71. SID. https://sid.ir/paper/619640/en

Vancouver: Copy

SOOSANABADI FARAHANI M., KAMALI K., KARIMLOU M., BANAN M., KHORRAM KHORSHID H.R.. ASSOCIATION STUDY BETWEEN BAT 1 GENE VARIATION AND LATE-ONSET (SPORADIC) ALZHEIMER’S DISEASE IN IRANIAN POPULATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(6 (75)):66-71. Available from: https://sid.ir/paper/619640/en

IEEE: Copy

M. SOOSANABADI FARAHANI, K. KAMALI, M. KARIMLOU, M. BANAN, and H.R. KHORRAM KHORSHID, “ASSOCIATION STUDY BETWEEN BAT 1 GENE VARIATION AND LATE-ONSET (SPORADIC) ALZHEIMER’S DISEASE IN IRANIAN POPULATION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 6 (75), pp. 66–71, 2013, [Online]. Available: https://sid.ir/paper/619640/en

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