VIRAL EVASION AND SUBVERSION MECHANISMS OF THE HOST IMMUNE SYSTEM

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GHAEMI BAFGHI MEHRAN; HAGHPARAST ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2013 | Volume:15 | Issue:10 Page(s): 1-6

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Information Journal Paper

Title

VIRAL EVASION AND SUBVERSION MECHANISMS OF THE HOST IMMUNE SYSTEM

Author(s)

GHAEMI BAFGHI MEHRAN | HAGHPARAST ALIREZA | Issue Writer Certificate

Keywords

VIRUS IMMUNE SYSTEM EVASION MECHANISMS

Abstract

Viruses are the most abundant and versatile pathogens which challenge the immune system and cause major threats to human health. Viruses employ different mechanisms to evade host immune responses that we describe them under the following headings: Inhibition of humoral responses, Interference with interferons, Inhibition and modulation of cytokines and chemokines, Inhibitors of apoptosis, Evading CTLs and NKs, and modulating MHC function.Viruses inhibit humoral immunity in different ways which contains change of viral antigens, production of regulatory proteins of complement system and receptors of the Fc part of antibodies. Viruses block interferon production and function via interruption of cell signaling JAK/STAT pathway, Inhibition of eIF-2a phosphorylation and translational arrest and 2’ 5’ OS/RNAse L system. Also, Poxviruses produce soluble versions of receptors for interferons. One of the most important ways of viral evasion is inhibition and manipulation of cytokines; for example, Herpsviruses and Poxviruses produce viral cytokines (virokines) and cytokine receptors (viroceptors). In addition, viruses change maturation and expression of MHC I and MHC II molecules to interrupt viral antigens presentation and hide them from immune system recognition. Also, they inhibit NK cell functions.In this review, we provide an overview of the viral evasion mechanisms of immune system. Since most viruses have developed strategies for evasion of immune system, if we know these mechanisms in detail we can fight them more successfully.

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APA: Copy

GHAEMI BAFGHI, MEHRAN, & HAGHPARAST, ALIREZA. (2013). VIRAL EVASION AND SUBVERSION MECHANISMS OF THE HOST IMMUNE SYSTEM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(10), 1-6. SID. https://sid.ir/paper/621539/en

Vancouver: Copy

GHAEMI BAFGHI MEHRAN, HAGHPARAST ALIREZA. VIRAL EVASION AND SUBVERSION MECHANISMS OF THE HOST IMMUNE SYSTEM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(10):1-6. Available from: https://sid.ir/paper/621539/en

IEEE: Copy

MEHRAN GHAEMI BAFGHI, and ALIREZA HAGHPARAST, “VIRAL EVASION AND SUBVERSION MECHANISMS OF THE HOST IMMUNE SYSTEM,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 10, pp. 1–6, 2013, [Online]. Available: https://sid.ir/paper/621539/en

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