THE EFFECTS OF ATORVASTATIN ON MUSTARD-GAS-EXPOSED PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED CONTROLLED TRIAL

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GHOBADI HASSAN; M. LARI SHAHRZAD; POURFARZI FARHAD; MAHMOUDPOUR AFSOUN; GHANEI MOSTAFA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:18 | Issue:2 Page(s): 99-105

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Title

THE EFFECTS OF ATORVASTATIN ON MUSTARD-GAS-EXPOSED PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED CONTROLLED TRIAL

Author(s)

Keywords

ATORVASTATIN

COPD

HS-CRP

SULFUR MUSTARD

Abstract

Background: Statins have anti-inflammatory effects in patients with chronic obstructive pulmonary disease (COPD). This study designed to evaluate the effects of ATORVASTATIN on serum highly sensitive C-reactive protein (hs-CRP) and pulmonary function in SULFUR MUSTARD exposed patients with COPD.Materials and Methods: Fifty patients with chronic obstructive pulmonary disease due to SULFUR MUSTARD and high serum HS-CRP entered in this study. Participants were randomized to receive 40 mg ATORVASTATIN or placebo in a double-blind clinical trial. Forty-five patients completed the study (n=23 ATORVASTATIN and n=22 placebo). Pulse oximetry (SpO2), pulmonary function test (PFT), and 6 min walk distance test (6MWD) was measured. COPD assessment test (CAT) and St. George's respiratory questionnaire (SGRQ) were also completed by patients at the beginning of trial and after 9 weeks of prescription of 40 mg/day ATORVASTATIN or placebo. At fourth week, SpO2, PFT, and 6MWD were again measured. After 9 weeks serum HS-CRP was re-measured.Results: There was no significant difference between ATORVASTATIN and the placebo group in SpO2, FEV1, and 6MWD after fourth week (P=0.79, P=0.12, P=0.12, respectively). The difference between baseline and ninth week was calculated for two groups of trial and control in term of serum HS-CRP, SpO2, FEV1, and 6MWD. Significant improvement was not observed between two groups in above mentioned variables (P=0.35, P=0.28, P=0.94, P=0.43, respectively). However, the quality of life was improved by administration of ATORVASTATIN using the CAT score (P<0.001) and SGRQ total score (P=0.004).Conclusion: ATORVASTATIN does not alter serum HS-CRP and lung functions but may improve quality of life in SM-injured patients with COPD.

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APA: Copy

GHOBADI, HASSAN, M. LARI, SHAHRZAD, POURFARZI, FARHAD, MAHMOUDPOUR, AFSOUN, & GHANEI, MOSTAFA. (2014). THE EFFECTS OF ATORVASTATIN ON MUSTARD-GAS-EXPOSED PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 18(2), 99-105. SID. https://sid.ir/paper/624304/en

Vancouver: Copy

GHOBADI HASSAN, M. LARI SHAHRZAD, POURFARZI FARHAD, MAHMOUDPOUR AFSOUN, GHANEI MOSTAFA. THE EFFECTS OF ATORVASTATIN ON MUSTARD-GAS-EXPOSED PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;18(2):99-105. Available from: https://sid.ir/paper/624304/en

IEEE: Copy

HASSAN GHOBADI, SHAHRZAD M. LARI, FARHAD POURFARZI, AFSOUN MAHMOUDPOUR, and MOSTAFA GHANEI, “THE EFFECTS OF ATORVASTATIN ON MUSTARD-GAS-EXPOSED PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED CONTROLLED TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 18, no. 2, pp. 99–105, 2014, [Online]. Available: https://sid.ir/paper/624304/en

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