DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO NEURAL CELLS: INSIGHTS FROM COMPARATIVE PROTEOMICS AND TRANSCRIPTOMICS ANALYSES; INVITED SPEAKERS

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FATHI A.; SHAHBAZI E.; VAKILIAN H.; BAHARVAND H.; HOSSEINI SALEKDEH GH.

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Journal: Cell Journal (Yakhteh) Year:2012 | Volume:14 | Issue:SUPPLEMENT 1 Page(s): 11-11

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Title

DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO NEURAL CELLS: INSIGHTS FROM COMPARATIVE PROTEOMICS AND TRANSCRIPTOMICS ANALYSES; INVITED SPEAKERS

Author(s)

FATHI A. | SHAHBAZI E. | VAKILIAN H. | BAHARVAND H. | HOSSEINI SALEKDEH GH.

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Abstract

Human embryonic stem cells (hESCs) are undifferentiated cells characterized by their functional capacity to both self-renewal and to differentiate into cell types representing the three embryonic germ lineages (e.g., ectoderm, mesoderm, and endoderm). Applying proteomics to explore the programs that control selfrenewal, differentiation, and plasticity will provide valuable insight into ESCs biology. We used a microarray- and DIGE-based transcriptome and proteome approaches, respectively, to analyze hESCs differentiation to neural cells at three different stages: early neural differentiation, neural ectoderm, and differentiated neural cells. Owing to comparative analyses, several proteins and mechanisms emerged as key participants in stem cells proliferation and differentiation. Furthermore, using siRNA approach, we analyzed the function of two genes, MAGOHB and BCAS2, which were down-regulated at both transcript and protein levels during neural differentiation. The knockdown of these genesresulted in an increase in the expression of neural progenitor markers such as PAX6 and NESTIN. The knockdown of BCAS2 led to a decrease in NANOG expression level and an increase in the abundance of P53. The suppression of MAGOHB resulted in down-regulation of early endoderm and mesodermal gene markers, suggesting that it may play a role in enhancing neurogenesis through inhibition of endomesodermal formation.

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APA: Copy

FATHI, A., SHAHBAZI, E., VAKILIAN, H., BAHARVAND, H., & HOSSEINI SALEKDEH, GH.. (2012). DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO NEURAL CELLS: INSIGHTS FROM COMPARATIVE PROTEOMICS AND TRANSCRIPTOMICS ANALYSES; INVITED SPEAKERS. CELL JOURNAL (YAKHTEH), 14(SUPPLEMENT 1), 11-11. SID. https://sid.ir/paper/627732/en

Vancouver: Copy

FATHI A., SHAHBAZI E., VAKILIAN H., BAHARVAND H., HOSSEINI SALEKDEH GH.. DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO NEURAL CELLS: INSIGHTS FROM COMPARATIVE PROTEOMICS AND TRANSCRIPTOMICS ANALYSES; INVITED SPEAKERS. CELL JOURNAL (YAKHTEH)[Internet]. 2012;14(SUPPLEMENT 1):11-11. Available from: https://sid.ir/paper/627732/en

IEEE: Copy

A. FATHI, E. SHAHBAZI, H. VAKILIAN, H. BAHARVAND, and GH. HOSSEINI SALEKDEH, “DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO NEURAL CELLS: INSIGHTS FROM COMPARATIVE PROTEOMICS AND TRANSCRIPTOMICS ANALYSES; INVITED SPEAKERS,” CELL JOURNAL (YAKHTEH), vol. 14, no. SUPPLEMENT 1, pp. 11–11, 2012, [Online]. Available: https://sid.ir/paper/627732/en

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