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Information Journal Paper

Title

HORMONAL AND METABOLIC EFFECTS OF POLYUNSATURATED FATTY ACID (OMEGA-3) ON POLYCYSTIC OVARY SYNDROME INDUCED RATS UNDER DIET

Pages

  123-127

Keywords

CATALAZE (CAT) 
FOLLICLE STIMULATING HORMONE (FSH) 
GLUTATHIONE PEROXIDASE (GPX) 
POLYCYSTIC OVARY (PCO) 
SUPER OXIDE DISMUTASE (SOD) 

Abstract

 Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing OMEGA-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats.Materials and Methods: Wistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: G1, received OMEGA-3 (240 mg/kg/orally/daily); G2 and G3 groups were induced PCO by single injection of estradiol-valerate (16 mg/kg/IM). Group 3 received OMEGA-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis.Results: Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received OMEGA-3 showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P<0.05) in comparison with other experimental groups. Ovarian weights in both experimental and control groups were similar (P<0.05). Level of serum FSH (follicle stimulating hormone) was decreased, but level of TESTOSTERONE was significantly increased (P<0.05) in PCO group in comparison with control and OMEGA-3 groups.Conclusion: Results revealed that administration of OMEGA-3 plus lower carbohydrate food significantly controlled PCO syndrome and balanced FSH and TESTOSTERONE.

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    APA: Copy

    OULADSAHEBMADAREK, ELAHEH, KHAKI, ARASH, KHANAHMADI, SHARAREH, AHMADI ASHTIANI, HAMIDREZA, PAKNEJAD, POOYA, & AYUBI, MOHAMMAD REZA. (2014). HORMONAL AND METABOLIC EFFECTS OF POLYUNSATURATED FATTY ACID (OMEGA-3) ON POLYCYSTIC OVARY SYNDROME INDUCED RATS UNDER DIET. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(2), 123-127. SID. https://sid.ir/paper/627869/en

    Vancouver: Copy

    OULADSAHEBMADAREK ELAHEH, KHAKI ARASH, KHANAHMADI SHARAREH, AHMADI ASHTIANI HAMIDREZA, PAKNEJAD POOYA, AYUBI MOHAMMAD REZA. HORMONAL AND METABOLIC EFFECTS OF POLYUNSATURATED FATTY ACID (OMEGA-3) ON POLYCYSTIC OVARY SYNDROME INDUCED RATS UNDER DIET. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(2):123-127. Available from: https://sid.ir/paper/627869/en

    IEEE: Copy

    ELAHEH OULADSAHEBMADAREK, ARASH KHAKI, SHARAREH KHANAHMADI, HAMIDREZA AHMADI ASHTIANI, POOYA PAKNEJAD, and MOHAMMAD REZA AYUBI, “HORMONAL AND METABOLIC EFFECTS OF POLYUNSATURATED FATTY ACID (OMEGA-3) ON POLYCYSTIC OVARY SYNDROME INDUCED RATS UNDER DIET,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 2, pp. 123–127, 2014, [Online]. Available: https://sid.ir/paper/627869/en

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