PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS

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TAHERI AHMAD REZA; MASHAYEKHI GOYONLO VAHID; NAHIDI YALDA; MOHEGHI NASRIN; TAVAKKOL AFSHARI JALIL

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:3 Page(s): 216-219

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Title

PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS

Author(s)

Keywords

CUTANEOUS LEISHMANIASIS

INTERFERON-γ

INTERLUKIN-4

T HELPER CELL

Abstract

Objective (s): In this study, the serum level of interferon-g (IFN-g) and INTERLUKIN-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of CUTANEOUS LEISHMANIASIS.Materials and Methods: This cross-sectional study was conducted on 44 cases of CUTANEOUS LEISHMANIASIS (21 cases with healed lesions and 23 cases with chronic non-healing lesions. Thirty-two non-infected persons living in the area were considered as controls. Serum levels of IFN- g and IL-4 were determined using ELISA, and the results along with clinical data were analyzed using SPSS 11.5.Results: Serum IFN-g level was not significantly different between various patient groups and control (P=0.27), but the serum level of IL-4 in patient groups was higher than in healthy subjects, and it was higher in patients with non-healed chronic CUTANEOUS LEISHMANIASIS than those with healed lesions (P<0.01).Conclusion: Serum IL-4 level is a good marker for evaluation of the clinical course of CUTANEOUS LEISHMANIASIS.

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APA: Copy

TAHERI, AHMAD REZA, MASHAYEKHI GOYONLO, VAHID, NAHIDI, YALDA, MOHEGHI, NASRIN, & TAVAKKOL AFSHARI, JALIL. (2014). PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 216-219. SID. https://sid.ir/paper/628142/en

Vancouver: Copy

TAHERI AHMAD REZA, MASHAYEKHI GOYONLO VAHID, NAHIDI YALDA, MOHEGHI NASRIN, TAVAKKOL AFSHARI JALIL. PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):216-219. Available from: https://sid.ir/paper/628142/en

IEEE: Copy

AHMAD REZA TAHERI, VAHID MASHAYEKHI GOYONLO, YALDA NAHIDI, NASRIN MOHEGHI, and JALIL TAVAKKOL AFSHARI, “PLASMA LEVELS OF INTERLUKIN-4 AND INTERFERON-γ IN PATIENTS WITH CHRONIC OR HEALED CUTANEOUS LEISHMANIASIS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 216–219, 2014, [Online]. Available: https://sid.ir/paper/628142/en

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