مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SPECTROFLUORIMETRIC DETERMINATION OF CEFIXIME USING TERBIUM-DANOFLOXACIN PROBE

Pages

  256-262

Abstract

 Objective (s): CEFIXIME (Cfx), is a semi-synthetic third-generation oral cephalosporin antibiotic that is prescribed for the treatment of susceptible infections. There are some procedures for the determination of Cfx in pharmaceutical formulations and biological samples. Herein a spectrofluorimetric method was proposed for Cfx determination based on the fluorescence QUENCHING of terbium-danofloxacin (Tb3+-Dano) in the presence of Cfx.Materials and Methods: Cfx was detected based on fluorescence QUENCHING of terbium-danofloxacin (Tb3+-Dano) in the presence of Cfx with maximum excitation and emission wavelengths at 347 nm and 545 nm, respectively. The quenched fluorescence intensity of Tb3+- Dano system is proportional to the concentration of Cfx. The optimum conditions for the determination of Cfx were studied.Results: The maximum response was achieved under optimum conditions of [Tris buffer]= 0.008 mol/l (pH 6.5), [Tb3+]=1×10-4 mol/l and [Dano]=1×10-4 mol/l. The developed method was evaluated in terms of accuracy, precision and limit of detection. The linear concentration ranges for quantification of Cfx were 8.8×10-8-8.8×10-7 mol/l and 1.1×10-7-8.8×10-7 mol/l in standard and human serum samples with the detection limits (S/N=3) of 2.8×10-8 mol/l and 3.9×10-8 mol/l, respectively. The Cfx was determined in pharmaceutical tablets and spiked serum samples and the results were satisfactory.Conclusion: This method is simple, practical and relatively interference-free for determination of Cfx in pharmaceutical tablets and serum samples.

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    APA: Copy

    MANZOORI, JAMSHID L., AMJADI, MOHAMMAD, SOLTANI, NASER, & JOUYBAN, ABOLGHASEM. (2014). SPECTROFLUORIMETRIC DETERMINATION OF CEFIXIME USING TERBIUM-DANOFLOXACIN PROBE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(4), 256-262. SID. https://sid.ir/paper/628159/en

    Vancouver: Copy

    MANZOORI JAMSHID L., AMJADI MOHAMMAD, SOLTANI NASER, JOUYBAN ABOLGHASEM. SPECTROFLUORIMETRIC DETERMINATION OF CEFIXIME USING TERBIUM-DANOFLOXACIN PROBE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(4):256-262. Available from: https://sid.ir/paper/628159/en

    IEEE: Copy

    JAMSHID L. MANZOORI, MOHAMMAD AMJADI, NASER SOLTANI, and ABOLGHASEM JOUYBAN, “SPECTROFLUORIMETRIC DETERMINATION OF CEFIXIME USING TERBIUM-DANOFLOXACIN PROBE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 4, pp. 256–262, 2014, [Online]. Available: https://sid.ir/paper/628159/en

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