CYSTATIN C, N-TERMINAL PROBRAIN NATRIURETIC PEPTIDES T-TERMINAL PROBRAIN NATRIURETIC PEPTIDES AND OUTCOMES IN ACUTE HEART FAILURE WITH ACUTE KIDNEY INJURY IN A 12-MONTH FOLLOW-UP: INSIGHTS INTO THE CARDIORENAL SYNDROME

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RUAN ZHONG BAO; ZHU LI; YIN YI GANG; CHEN GE CAI

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:19 | Issue:5 Page(s): 404-409

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Title

CYSTATIN C, N-TERMINAL PROBRAIN NATRIURETIC PEPTIDES T-TERMINAL PROBRAIN NATRIURETIC PEPTIDES AND OUTCOMES IN ACUTE HEART FAILURE WITH ACUTE KIDNEY INJURY IN A 12-MONTH FOLLOW-UP: INSIGHTS INTO THE CARDIORENAL SYNDROME

Author(s)

RUAN ZHONG BAO | ZHU LI | YIN YI GANG | CHEN GE CAI | Issue Writer Certificate

Keywords

ACUTE HEART FAILURE

ACUTE KIDNEY INJURY

CARDIORENAL SYNDROME

CYSTATIN C

TERMINAL PROBRAIN NATRIURETIC PEPTIDES

Abstract

Background: CYSTATIN C (Cys C) has been implicated as a prognostic marker in cardiovascular disease. The aim of this study was to evaluate the value of Cys C as a marker of ACUTE KIDNEY INJURY (AKI) in ACUTE HEART FAILURE (AHF), the impact of Cys C and N-terminal probrain Natriuretic peptides (NT-proBNP) on in-hospital and 12 months mortality were also investigated.Materials and Methods: A total of 162 patients with AHF were enrolled. NT-proBNP, Cys C, serum creatinine (Scr), blood urea Nitrogen (BUN) and parameters of echocardiography were measured for analyze. The in-hospital and 12 months mortality was analyzed.Results: There was 28 (17%) of all AHF patients with AKI. Compared with No-AKI patients, the levels of Cys C (1.51±0.34vs. 1.32±0.29, P=0.003) and NT-proBNP (8163.87±898.06 vs. 5922.45±576.73, P=0.001) were higher in AKI patients. Higher levels of NT-proBNP (odds ratio (OR)=1.92, 95% confidence interval (CI): 2.19-10.98, P=0.018, OR=4.31, 95% CI: 2.35-9.82,P=0.002, respectively) and Cys C (OR=1.48, 95% CI: 1.75-4.16, P=0.027, OR=2.72, 95% CI: 1.92-4.28, P=0.017, respectively)were independent association with the in-hospital and 12 months mortality. Cys C was positively correlated with NT-proBNP (r=0.87, P<0.001). Combining tertiles of Cys C and NT-proBNP improved risk stratification further. Compared with patients without AKI CysC, patients with AKI cysC was associated with higher in-hospital (7.28 vs. 10.134, P=0.002) and 12-month mortality (13.28 vs. 32.134, P=0.001).Conclusion: Cys C was Not only a promising risk marker in patients hospitalized for AHF, but also an independent predictor of 12-month mortality. Combining tertiles of Cys C and NT-proBNP could be used to distinguish the mortality risk identification of patients with AHF. AKI was an independent predictor of in-hospital and 12-month mortality.

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APA: Copy

RUAN, ZHONG BAO, ZHU, LI, YIN, YI GANG, & CHEN, GE CAI. (2014). CYSTATIN C, N-TERMINAL PROBRAIN NATRIURETIC PEPTIDES T-TERMINAL PROBRAIN NATRIURETIC PEPTIDES AND OUTCOMES IN ACUTE HEART FAILURE WITH ACUTE KIDNEY INJURY IN A 12-MONTH FOLLOW-UP: INSIGHTS INTO THE CARDIORENAL SYNDROME. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 19(5), 404-409. SID. https://sid.ir/paper/629346/en

Vancouver: Copy

RUAN ZHONG BAO, ZHU LI, YIN YI GANG, CHEN GE CAI. CYSTATIN C, N-TERMINAL PROBRAIN NATRIURETIC PEPTIDES T-TERMINAL PROBRAIN NATRIURETIC PEPTIDES AND OUTCOMES IN ACUTE HEART FAILURE WITH ACUTE KIDNEY INJURY IN A 12-MONTH FOLLOW-UP: INSIGHTS INTO THE CARDIORENAL SYNDROME. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;19(5):404-409. Available from: https://sid.ir/paper/629346/en

IEEE: Copy

ZHONG BAO RUAN, LI ZHU, YI GANG YIN, and GE CAI CHEN, “CYSTATIN C, N-TERMINAL PROBRAIN NATRIURETIC PEPTIDES T-TERMINAL PROBRAIN NATRIURETIC PEPTIDES AND OUTCOMES IN ACUTE HEART FAILURE WITH ACUTE KIDNEY INJURY IN A 12-MONTH FOLLOW-UP: INSIGHTS INTO THE CARDIORENAL SYNDROME,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 19, no. 5, pp. 404–409, 2014, [Online]. Available: https://sid.ir/paper/629346/en

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