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Information Journal Paper

Title

IMPROVEMENT IN MEMORY AND BRAIN LONG-TERM POTENTIATION DEFICITS DUE TO PERMANENT HYPOPERFUSION/ISCHEMIA BY GRAPE SEED EXTRACT IN RATS

Pages

  1004-1010

Abstract

 Objective(s): Cerebral HYPOPERFUSION/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of GRAPE SEED EXTRACT (GSE) on passive avoidance MEMORY and long-term potentiation (LTP) after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult RATs.Materials and Methods: Thirty-two adult male Wistar RATs were randomly divided into: 1) Sham+Veh, 2) Isch+Veh, 3) Sham+GSE, 4) Isch+GSE. In order to make 2CCAO as an animal model of CHI, carotid arteries were ligatured and then cut bilaterally. To evaluation of passive avoidance MEMORY, step-down latency (STL) was measured and LTP was recorded from hippocampal dentate gyrus (DG) after high frequency stimulation (HFS) in all RATs.Results: We found that MEMORY was significantly impaired in RATs after CHI (P<0.001) concomitant with hippocampal LTP inhibition (P<0.05, P<0.01 for LTP1 and LTP48 respectively). GSE treatment significantly improved MEMORY impairment and increased hippocampal LTP in RATs with 2CCAO.Conclusion: Our results in present study suggest that GSE exhibits therapeutic potential for short-and long-term memories as well as LTP in DG, which is most likely related at least in part to its antioxidative and free radical scavenging actions.

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    APA: Copy

    SARKAKI, ALIREZA, RAFIEIRAD, MARYAM, HOSSINI, SEYED EBRAHIM, FARBOOD, YAGHOUB, MOTAMEDI, FERESHTEH, MANSOURI, SEYED MOHAMMAD TAGHI, & NAGHIZADEH, BAHAREH. (2013). IMPROVEMENT IN MEMORY AND BRAIN LONG-TERM POTENTIATION DEFICITS DUE TO PERMANENT HYPOPERFUSION/ISCHEMIA BY GRAPE SEED EXTRACT IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(9), 1004-1010. SID. https://sid.ir/paper/629394/en

    Vancouver: Copy

    SARKAKI ALIREZA, RAFIEIRAD MARYAM, HOSSINI SEYED EBRAHIM, FARBOOD YAGHOUB, MOTAMEDI FERESHTEH, MANSOURI SEYED MOHAMMAD TAGHI, NAGHIZADEH BAHAREH. IMPROVEMENT IN MEMORY AND BRAIN LONG-TERM POTENTIATION DEFICITS DUE TO PERMANENT HYPOPERFUSION/ISCHEMIA BY GRAPE SEED EXTRACT IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(9):1004-1010. Available from: https://sid.ir/paper/629394/en

    IEEE: Copy

    ALIREZA SARKAKI, MARYAM RAFIEIRAD, SEYED EBRAHIM HOSSINI, YAGHOUB FARBOOD, FERESHTEH MOTAMEDI, SEYED MOHAMMAD TAGHI MANSOURI, and BAHAREH NAGHIZADEH, “IMPROVEMENT IN MEMORY AND BRAIN LONG-TERM POTENTIATION DEFICITS DUE TO PERMANENT HYPOPERFUSION/ISCHEMIA BY GRAPE SEED EXTRACT IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 9, pp. 1004–1010, 2013, [Online]. Available: https://sid.ir/paper/629394/en

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