GLUTATHIONE S-TRANSFERASE M1 AND T1 GENETIC POLYMORPHISMS IN IRANIAN PATIENTS WITH GLAUCOMA

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KAZEMI SAFA FATEMEH; SHAHSAVARI GHOLAMREZA; ZARE ABYANEH REZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:5 Page(s): 332-336

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Information Journal Paper

Title

GLUTATHIONE S-TRANSFERASE M1 AND T1 GENETIC POLYMORPHISMS IN IRANIAN PATIENTS WITH GLAUCOMA

Author(s)

KAZEMI SAFA FATEMEH | SHAHSAVARI GHOLAMREZA | ZARE ABYANEH REZA | Issue Writer Certificate

Keywords

GLAUCOMA

GLUTATHIONE S-TRANSFERASES

PRIMARY CLOSED ANGLE GLAUCOMA

PRIMARY OPEN ANGLE GLAUCOMA

Abstract

Objective (s): GLAUCOMA is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. GLUTATHIONE S-TRANSFERASES (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 GLAUCOMA patients (41with primary open angle GLAUCOMA (PCAG), and 59 with primary closed angle GLAUCOMA (POAG)) compared to 100 healthy subjects.Materials and Methods: GSTM1and GSTT1 polymorphisms were determined by multiplex polymerase chain reaction.Results: GSTM1 and GSTT1 null deletions genotypes were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy subjects. Comparison between patients and healthy subjects regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes in patients with PCAG (P=0.03).Conclusion: It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population.

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APA: Copy

KAZEMI SAFA, FATEMEH, SHAHSAVARI, GHOLAMREZA, & ZARE ABYANEH, REZA. (2014). GLUTATHIONE S-TRANSFERASE M1 AND T1 GENETIC POLYMORPHISMS IN IRANIAN PATIENTS WITH GLAUCOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(5), 332-336. SID. https://sid.ir/paper/629406/en

Vancouver: Copy

KAZEMI SAFA FATEMEH, SHAHSAVARI GHOLAMREZA, ZARE ABYANEH REZA. GLUTATHIONE S-TRANSFERASE M1 AND T1 GENETIC POLYMORPHISMS IN IRANIAN PATIENTS WITH GLAUCOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(5):332-336. Available from: https://sid.ir/paper/629406/en

IEEE: Copy

FATEMEH KAZEMI SAFA, GHOLAMREZA SHAHSAVARI, and REZA ZARE ABYANEH, “GLUTATHIONE S-TRANSFERASE M1 AND T1 GENETIC POLYMORPHISMS IN IRANIAN PATIENTS WITH GLAUCOMA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 5, pp. 332–336, 2014, [Online]. Available: https://sid.ir/paper/629406/en

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