PKCA AGONISTS ENHANCE THE PROTECTIVE EFFECT OF HYALURONIC ACID ON NITRIC OXIDE-INDUCED APOPTOSIS OF ARTICULAR CHONDROCYTES IN VITRO

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ZHOU JIAN LIN; FANG HONG SONG; PENG HAO; HU QIONG JIE; LIU SHI QING; MING JIANG HUA; QIU BO

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Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:12 Page(s): 1276-1281

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Title

PKCA AGONISTS ENHANCE THE PROTECTIVE EFFECT OF HYALURONIC ACID ON NITRIC OXIDE-INDUCED APOPTOSIS OF ARTICULAR CHONDROCYTES IN VITRO

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Keywords

APOPTOSIS

NITRIC OXIDE

PKC-α

PMA

Abstract

Objective (s): Protein kinase C (PKCα) is involved in modulating articular chondrocytes APOPTOSIS induced by NITRIC OXIDE (NO). Hyaluronic acid (HA) inhibits NITRIC OXIDE-induced APOPTOSIS of articular chondrocytes by protecting PKCα, but the mechanism remains unclear. The present study was performed to investigate the effects and mechanisms of PKCα regulate protective effect of hyaluronic acid.Materials and Methods The ratio of apoptotic cell and cell viability was surveyed by PCNA and MTT assay. The expression of caspase-3 was determined by real-time PCR and western blot.Results: It was showed that HA was able to reduce the nuclei fragment and PCNA expression, and NO-induced articular APOPTOSIS blocked by HA, pretreated chondrocytes with PMA, HA significantly inhibits the activation of caspase-3 induced by NO, but pretrement with CHR, HA significantly incresed the expression of caspase-3.Conclusion: The results may be showed that PKCa regulate the expresion of caspase-3, which contribute to the APOPTOSIS of chondrocytes induced by NO. PKC α agonists enhance the protective effect of hyaluronic acid on NITRIC OXIDE-induced articular chondrocytes APOPTOSIS.

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APA: Copy

ZHOU, JIAN LIN, FANG, HONG SONG, PENG, HAO, HU, QIONG JIE, LIU, SHI QING, MING, JIANG HUA, & QIU, BO. (2013). PKCA AGONISTS ENHANCE THE PROTECTIVE EFFECT OF HYALURONIC ACID ON NITRIC OXIDE-INDUCED APOPTOSIS OF ARTICULAR CHONDROCYTES IN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1276-1281. SID. https://sid.ir/paper/629462/en

Vancouver: Copy

ZHOU JIAN LIN, FANG HONG SONG, PENG HAO, HU QIONG JIE, LIU SHI QING, MING JIANG HUA, QIU BO. PKCA AGONISTS ENHANCE THE PROTECTIVE EFFECT OF HYALURONIC ACID ON NITRIC OXIDE-INDUCED APOPTOSIS OF ARTICULAR CHONDROCYTES IN VITRO. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(12):1276-1281. Available from: https://sid.ir/paper/629462/en

IEEE: Copy

JIAN LIN ZHOU, HONG SONG FANG, HAO PENG, QIONG JIE HU, SHI QING LIU, JIANG HUA MING, and BO QIU, “PKCA AGONISTS ENHANCE THE PROTECTIVE EFFECT OF HYALURONIC ACID ON NITRIC OXIDE-INDUCED APOPTOSIS OF ARTICULAR CHONDROCYTES IN VITRO,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 12, pp. 1276–1281, 2013, [Online]. Available: https://sid.ir/paper/629462/en

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