مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ENZYME INHIBITORY AND RADICAL SCAVENGING EFFECTS OF SOME ANTIDIABETIC PLANTS OF TURKEY

Pages

  426-432

Abstract

 Objective(s): Ethnopharmacological field surveys demonstrated that many plants, such as GENTIANA OLIVIERi, HELICHRYSUM graveolens, HELICHRYSUM plicatum ssp. plicatum, JUNIPERUS oxycedrus ssp. oxycedrus, JUNIPERUS communis var. saxatilis, VISCUM ALBUM (ssp. album, ssp. austriacum), are used as traditional medicine for diabetes in different regions of Anatolia. The present study was designed to evaluate the in vitro antidiabetic effects of some selected plants, tested in animal models recently.Materials and Methods: a-glucosidase and α-amylase enzyme inhibitory effects of the plant extracts were investigated and Acarbose was used as a reference drug. Additionally, radical scavenging capacities were determined using 2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ABTS radical cation scavenging assay and total phenolic content of the extracts were evaluated using Folin Ciocalteu method.Results: H. graveolens ethanol extract exhibited the highest inhibitory activity (55.7%±2.2) on a-amylase enzyme. Additionally, J. oxycedrus hydro-alcoholic leaf extract had potent a-amylase inhibitory effect, while the hydro-alcoholic extract of J. communis fruit showed the highest a-glucosidase inhibitory activity (IC50: 4.4 mg/ml).Conclusion: Results indicated that, antidiabetic effect of hydro-alcoholic extracts of H. graveolens capitulums, J. communis fruit and J. oxycedrus leaf might arise from inhibition of digestive enzymes.

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    APA: Copy

    ORHAN, NILUFER, HOSBAS, SANEM, ORHAN, DIDEM DELIORMAN, ASLAN, MUSTAFA, & ERGUN, FATMA. (2014). ENZYME INHIBITORY AND RADICAL SCAVENGING EFFECTS OF SOME ANTIDIABETIC PLANTS OF TURKEY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(6), 426-432. SID. https://sid.ir/paper/629669/en

    Vancouver: Copy

    ORHAN NILUFER, HOSBAS SANEM, ORHAN DIDEM DELIORMAN, ASLAN MUSTAFA, ERGUN FATMA. ENZYME INHIBITORY AND RADICAL SCAVENGING EFFECTS OF SOME ANTIDIABETIC PLANTS OF TURKEY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(6):426-432. Available from: https://sid.ir/paper/629669/en

    IEEE: Copy

    NILUFER ORHAN, SANEM HOSBAS, DIDEM DELIORMAN ORHAN, MUSTAFA ASLAN, and FATMA ERGUN, “ENZYME INHIBITORY AND RADICAL SCAVENGING EFFECTS OF SOME ANTIDIABETIC PLANTS OF TURKEY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 6, pp. 426–432, 2014, [Online]. Available: https://sid.ir/paper/629669/en

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