IN SILICO ANALYSIS OF CHIMERIC TF, OMP31 AND BP26 FRAGMENTS OF BRUCELLA MELITENSIS FOR DEVELOPMENT OF A MULTI SUBUNIT VACCINE CANDIDATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHASEMI AMIR; RANJBAR REZA; AMANI JAFAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:3 Page(s): 172-180

Download Full-Text

View:

351

Download:

428

Cites:

Information Journal Paper

Title

IN SILICO ANALYSIS OF CHIMERIC TF, OMP31 AND BP26 FRAGMENTS OF BRUCELLA MELITENSIS FOR DEVELOPMENT OF A MULTI SUBUNIT VACCINE CANDIDATE

Author(s)

GHASEMI AMIR | RANJBAR REZA | AMANI JAFAR | Issue Writer Certificate

Keywords

BRUCELLOSIS

CHIMERIC PROTEIN

EPITOPE

VACCINATION

Abstract

Objective (s): BRUCELLOSIS, especially caused by Brucella melitensis, remains one of the most common zoonotic diseases worldwide with more than 500, 000 human cases reported annually. The commonly used live attenuated vaccine in ovine BRUCELLOSIS prophylaxis is B. melitensis Rev1. But due to different problems caused by the administration of this vaccine, a protective subunit vaccine against B. melitensis is strongly demanded. Brucella BP26, Omp31 and TF proteins have shown a considerable potential as protective antigens for BRUCELLOSIS. CHIMERIC PROTEINs carrying EPITOPEs or adjuvant sequences increase the possibility of eliciting a broad cellular or humoral immune response. In silico tools are highly suited to study, design and evaluate vaccine strategies.Materials and Methods: In this study, a synthetic chimeric gene, encoding TF, BP26 93-111 and Omp3148-74 was designed. In order to predict the 3D structure of protein, modeling was carried out.Results: Validation results showed that 91.1% of residues lie in favored or additional allowed region of Ramachandran plot. The EPITOPEs in the CHIMERIC PROTEIN are likely to induce both the B-cell and T-cell mediated immune responses.Conclusion: The CHIMERIC PROTEIN may be used as multi subunit for development of Brucella vaccine candidates.

Cites

B AND T-CELL EPITOPE PREDICTION OF THE OMP25 ANTIGEN FOR DEVELOPING BRUCELLA MELITENSIS VACCINES FOR SHEEP

References

No record.

Cite

APA: Copy

GHASEMI, AMIR, RANJBAR, REZA, & AMANI, JAFAR. (2014). IN SILICO ANALYSIS OF CHIMERIC TF, OMP31 AND BP26 FRAGMENTS OF BRUCELLA MELITENSIS FOR DEVELOPMENT OF A MULTI SUBUNIT VACCINE CANDIDATE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 172-180. SID. https://sid.ir/paper/629674/en

Vancouver: Copy

GHASEMI AMIR, RANJBAR REZA, AMANI JAFAR. IN SILICO ANALYSIS OF CHIMERIC TF, OMP31 AND BP26 FRAGMENTS OF BRUCELLA MELITENSIS FOR DEVELOPMENT OF A MULTI SUBUNIT VACCINE CANDIDATE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):172-180. Available from: https://sid.ir/paper/629674/en

IEEE: Copy

AMIR GHASEMI, REZA RANJBAR, and JAFAR AMANI, “IN SILICO ANALYSIS OF CHIMERIC TF, OMP31 AND BP26 FRAGMENTS OF BRUCELLA MELITENSIS FOR DEVELOPMENT OF A MULTI SUBUNIT VACCINE CANDIDATE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 172–180, 2014, [Online]. Available: https://sid.ir/paper/629674/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops