مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

310
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

193
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EVALUATION OF SYNTHETIC ZEOLITES AS ORAL DELIVERY VEHICLE FOR ANTI-INFLAMMATORY DRUGS

Pages

  337-343

Abstract

 Objective (s): In this research, ZEOLITE X and ZEOLITE Y were used as vehicle to prepare intestine targeted oral delivery systems of INDOMETHACIN and IBUPROFEN.Materials and Methods: A soaking procedure was implemented to encapsulate INDOMETHACIN or IBUPROFEN within synthetic ZEOLITEs. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into ZEOLITE structures. Scanning Electron Microscopy (SEM) was also utilized to determine morphologies changes in synthetic ZEOLITEs after drug loading. At the next stage, dissolution studies were used to predict the in vivo performance of prepared formulations at HCl 0.1 N and PBS pH 6.5 as simulated gastric fluid (SGF) and simulated intestine fluid (SIF), respectively.Results: Drug loadings of prepared formulations was determined between 24-26% w/w. Dissolution tests at SGF were shown that ZEOLITEs could retain acidic model drugs in their porous structures and can be able to limit their release into the stomach. On the other hand, all prepared formulations completely released model drugs during 3 hr in simulated intestine fluid.Conclusion: Obtained results indicated ZEOLITEs could potentially be able to release INDOMETHACIN and IBUPROFEN in a sustained and controlled manner and reduced adverse effects commonly accompanying oral administrations of NSAIDs.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    KHODAVERDI, ELHAM, HONARMANDI, REZA, ALIBOLANDI, MONA, RAFATPANAH BAYGI, ROXANA, HADIZADEH, FARZIN, & ZOHURI, GHOLAMHOSSEIN. (2014). EVALUATION OF SYNTHETIC ZEOLITES AS ORAL DELIVERY VEHICLE FOR ANTI-INFLAMMATORY DRUGS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(5), 337-343. SID. https://sid.ir/paper/629675/en

    Vancouver: Copy

    KHODAVERDI ELHAM, HONARMANDI REZA, ALIBOLANDI MONA, RAFATPANAH BAYGI ROXANA, HADIZADEH FARZIN, ZOHURI GHOLAMHOSSEIN. EVALUATION OF SYNTHETIC ZEOLITES AS ORAL DELIVERY VEHICLE FOR ANTI-INFLAMMATORY DRUGS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(5):337-343. Available from: https://sid.ir/paper/629675/en

    IEEE: Copy

    ELHAM KHODAVERDI, REZA HONARMANDI, MONA ALIBOLANDI, ROXANA RAFATPANAH BAYGI, FARZIN HADIZADEH, and GHOLAMHOSSEIN ZOHURI, “EVALUATION OF SYNTHETIC ZEOLITES AS ORAL DELIVERY VEHICLE FOR ANTI-INFLAMMATORY DRUGS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 5, pp. 337–343, 2014, [Online]. Available: https://sid.ir/paper/629675/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button