مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF RUBIA TINCTORUM L. EXTRACTSON CARRAGEENAN-INDUCED PAW EDEMA IN RATS

Pages

  62-70

Abstract

 Background: Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as ANTI-INFLAMMATORY agents since very early times. RUBIA TINCTORUM L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine.Objective: This study aims at considering ANTI-INFLAMMATORY effects of R. tinctorum and comparing its extracts in this property.Methods: The root of RUBIA TINCTORUM (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their ANTI-INFLAMMATORY activity by using CARRAGEENAN-induced hind PAW EDEMA in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before CARRAGEENAN injection. The paw thickness was measured at 1, 3 and 5 hours after injection.Results: Both, aqueous and 50% eq. ethanolic extracts reduced PAW EDEMA at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after CARRAGEENAN injection.Conclusion: The results indicated that the aqueous extract were exhibited higher ANTI-INFLAMMATORY effect compared with other extracts. Accordingly, the potent ANTI-INFLAMMATORY effect of the root extracts is attributed to the polar compounds which are extracted in the water.

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    Cite

    APA: Copy

    SHARIFZADEH, M., EBADI, N., MANAYI, A., KAMALINEJAD, M., REZAEIZADEH, H., MIRABZADEH, M., BONAKDAR YAZDI, B., & KHANAVI, M.. (2014). EFFECT OF RUBIA TINCTORUM L. EXTRACTSON CARRAGEENAN-INDUCED PAW EDEMA IN RATS. JOURNAL OF MEDICINAL PLANTS, 13(51), 62-70. SID. https://sid.ir/paper/630109/en

    Vancouver: Copy

    SHARIFZADEH M., EBADI N., MANAYI A., KAMALINEJAD M., REZAEIZADEH H., MIRABZADEH M., BONAKDAR YAZDI B., KHANAVI M.. EFFECT OF RUBIA TINCTORUM L. EXTRACTSON CARRAGEENAN-INDUCED PAW EDEMA IN RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2014;13(51):62-70. Available from: https://sid.ir/paper/630109/en

    IEEE: Copy

    M. SHARIFZADEH, N. EBADI, A. MANAYI, M. KAMALINEJAD, H. REZAEIZADEH, M. MIRABZADEH, B. BONAKDAR YAZDI, and M. KHANAVI, “EFFECT OF RUBIA TINCTORUM L. EXTRACTSON CARRAGEENAN-INDUCED PAW EDEMA IN RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 13, no. 51, pp. 62–70, 2014, [Online]. Available: https://sid.ir/paper/630109/en

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