EVALUATION OF RELATIVE POTENCY OF HUMAN TUBERCULIN SKIN TEST IN THE GUINEA PIGS SENSITIZED WITH MYCOBACTERIUM TUBERCULOSIS, M. BOVIS BCG AND M. AVIUM

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SADEGHI GARIZ DAVOUD; MOSAVARI NADER; RAFIEE BEHNAM; DASHTIPOUR SHOJAAT; SAKHRAVI AHMAD; HESHMATI EMRAN; ZARE ABBAS

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Journal: Zahedan Journal of Research in Medical Sciences Year:2013 | Volume:15 | Issue:12 Page(s): 1-4

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Title

EVALUATION OF RELATIVE POTENCY OF HUMAN TUBERCULIN SKIN TEST IN THE GUINEA PIGS SENSITIZED WITH MYCOBACTERIUM TUBERCULOSIS, M. BOVIS BCG AND M. AVIUM

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Keywords

HUMAN TUBERCULIN SKIN TEST

MYCOBACTERIUM TUBERCULOSIS

MYCOBACTERIUM AVIUM

MYCOBACTERIUM BOVIS

BCG

Abstract

Background: The tuberculin skin test is the most commonly used test for diagnosing tuberculosis (TB) infection. The basis of tuberculin testing is the induction of a delayed hypersensitivity reaction to the intradermal injection of tuberculin. Unfortunately, this test is incapable of distinguishing MYCOBACTERIUM TUBERCULOSIS infection from Bacille Calmette-Guerin (BCG) vaccination or infection with non-tuberculous mycobacteria. The aim of this study is to evaluate the relative potency of HUMAN TUBERCULIN SKIN TEST (produced by Razi Vaccine and Serum Research Institute) in the guinea pigs sensitized with M. tuberculosis, M. bovis BCG and M. avium.Materials and Methods: For skin test, different groups of guinea pigs were sensitized with M. tuberculosis, M. avium and M. bovis BCG. Guinea pigs were injected intradermally with 0.1 ml of 0.4, 2 and 10 mg/ml of tuberculin. Skin reactions (diameters of erythema, in millimeters) were independently measured 24 h after injection and results were calculated.Results: The results showed that the specificity index of human tuberculin test for guinea pigs sensitized with M. bovis BCG in compare of guinea pigs sensitized with M. tuberculosis was equal and for guinea pigs sensitized with M. avium was not equal.Conclusion: This study demonstrated that human tuberculin test produced by Razi Institute for diagnosis of latent infection to M. tuberculosis has lower specificity for M. bovis in comparison with M. avium.

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APA: Copy

SADEGHI GARIZ, DAVOUD, MOSAVARI, NADER, RAFIEE, BEHNAM, DASHTIPOUR, SHOJAAT, SAKHRAVI, AHMAD, HESHMATI, EMRAN, & ZARE, ABBAS. (2013). EVALUATION OF RELATIVE POTENCY OF HUMAN TUBERCULIN SKIN TEST IN THE GUINEA PIGS SENSITIZED WITH MYCOBACTERIUM TUBERCULOSIS, M. BOVIS BCG AND M. AVIUM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 15(12), 1-4. SID. https://sid.ir/paper/630492/en

Vancouver: Copy

SADEGHI GARIZ DAVOUD, MOSAVARI NADER, RAFIEE BEHNAM, DASHTIPOUR SHOJAAT, SAKHRAVI AHMAD, HESHMATI EMRAN, ZARE ABBAS. EVALUATION OF RELATIVE POTENCY OF HUMAN TUBERCULIN SKIN TEST IN THE GUINEA PIGS SENSITIZED WITH MYCOBACTERIUM TUBERCULOSIS, M. BOVIS BCG AND M. AVIUM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2013;15(12):1-4. Available from: https://sid.ir/paper/630492/en

IEEE: Copy

DAVOUD SADEGHI GARIZ, NADER MOSAVARI, BEHNAM RAFIEE, SHOJAAT DASHTIPOUR, AHMAD SAKHRAVI, EMRAN HESHMATI, and ABBAS ZARE, “EVALUATION OF RELATIVE POTENCY OF HUMAN TUBERCULIN SKIN TEST IN THE GUINEA PIGS SENSITIZED WITH MYCOBACTERIUM TUBERCULOSIS, M. BOVIS BCG AND M. AVIUM,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 15, no. 12, pp. 1–4, 2013, [Online]. Available: https://sid.ir/paper/630492/en

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