SYNTHESIS, ANTI-INFLAMMATORY AND ANTI- NOCICEPTIVE ACTIVITIES AND CYTOTOXIC EFFECT OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES AS SELECTIVE CYCLOOXYGENASE (COX-2) INHIBITORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOALLEM SEYED ADEL; IMENSHAHIDI MOHSEN; SHAHINI NARGES; JAVAN AHMAD REZA; KARIMI MOHSEN; ALIBOLANDI MONA; GHANDADI MORTEZA; ETEMAD LEILA; MOTAMEDSHARIATY VAHIDEHSADAT; HOSSEINI TOKTAM; HADIZADEH FARZIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2013 | Volume:16 | Issue:12 Page(s): 1238-1244

Download Full-Text

View:

309

Download:

266

Cites:

Information Journal Paper

Title

SYNTHESIS, ANTI-INFLAMMATORY AND ANTI- NOCICEPTIVE ACTIVITIES AND CYTOTOXIC EFFECT OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES AS SELECTIVE CYCLOOXYGENASE (COX-2) INHIBITORS

Author(s)

Keywords

ANTINOCICEPTIVE

ANTI-INFLAMMATORY

ANTICANCER

CELECOXIB

COX-2 INHIBITOR

THIAZOLIDIN-4-ONES

Abstract

Objective (s): Nowadays, COX-2 INHIBITORs such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. In response to this, medicinal chemists have attempted to synthesize new classes of COX-2 INHIBITORs.Materials and Methods: In this study, three novel analogues of THIAZOLIDIN-4-ONES derivatives 2a-c were synthesized. The ability of these compounds to inhibit ovine COX-1 and COX-2 (0.2- 0.8 μM) was determined using a colorimetric method. The cytotoxic effect of the synthesized compounds (25-100 mM) was also investigated by measuring their cytotoxicity against Caco-2 and MCF-7 cell lines using MTT assay. Cell apoptosis was determined by flow cytometry. Writhing test (7.5-75 mg/kg) was used to examine the ANTINOCICEPTIVE effects in mice. The effect of the analogues against acute inflammation (7.5-75 mg/kg) was also studied using xylene-induced ear edema test in mice.Results: The synthesized compounds showed a weak capacity to inhibit the proliferation of Caco-2 and MCF-7 cell lines. The COX-2 inhibition potency and selectivity index for test compounds 2a–b were as follows; CELECOXIB>2b>2a. On the other hand, all three analogues exhibited strong ANTINOCICEPTIVE activity against acetic acid-induced writhing. The ANTI-INFLAMMATORY and ANTINOCICEPTIVE effects of the analogues were markedly more than positive control, CELECOXIB.Conclusion: This study demonstrates that the ANTINOCICEPTIVE and ANTI-INFLAMMATORY activity profiles exhibited by the novel synthesized compounds are independent from their COX-2 INHIBITORy potencies. The found ANTINOCICEPTIVE and ANTI-INFLAMMATORY effects can be caused by interaction with other target; independent from COX-2. Accordingly, the compounds 2a-c could serve as lead compounds to develop novel anti-inflammation and ANTINOCICEPTIVE drugs.

Cites

No record.

References

No record.

Cite

APA: Copy

MOALLEM, SEYED ADEL, IMENSHAHIDI, MOHSEN, SHAHINI, NARGES, JAVAN, AHMAD REZA, KARIMI, MOHSEN, ALIBOLANDI, MONA, GHANDADI, MORTEZA, ETEMAD, LEILA, MOTAMEDSHARIATY, VAHIDEHSADAT, HOSSEINI, TOKTAM, & HADIZADEH, FARZIN. (2013). SYNTHESIS, ANTI-INFLAMMATORY AND ANTI- NOCICEPTIVE ACTIVITIES AND CYTOTOXIC EFFECT OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES AS SELECTIVE CYCLOOXYGENASE (COX-2) INHIBITORS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(12), 1238-1244. SID. https://sid.ir/paper/630936/en

Vancouver: Copy

MOALLEM SEYED ADEL, IMENSHAHIDI MOHSEN, SHAHINI NARGES, JAVAN AHMAD REZA, KARIMI MOHSEN, ALIBOLANDI MONA, GHANDADI MORTEZA, ETEMAD LEILA, MOTAMEDSHARIATY VAHIDEHSADAT, HOSSEINI TOKTAM, HADIZADEH FARZIN. SYNTHESIS, ANTI-INFLAMMATORY AND ANTI- NOCICEPTIVE ACTIVITIES AND CYTOTOXIC EFFECT OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES AS SELECTIVE CYCLOOXYGENASE (COX-2) INHIBITORS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(12):1238-1244. Available from: https://sid.ir/paper/630936/en

IEEE: Copy

SEYED ADEL MOALLEM, MOHSEN IMENSHAHIDI, NARGES SHAHINI, AHMAD REZA JAVAN, MOHSEN KARIMI, MONA ALIBOLANDI, MORTEZA GHANDADI, LEILA ETEMAD, VAHIDEHSADAT MOTAMEDSHARIATY, TOKTAM HOSSEINI, and FARZIN HADIZADEH, “SYNTHESIS, ANTI-INFLAMMATORY AND ANTI- NOCICEPTIVE ACTIVITIES AND CYTOTOXIC EFFECT OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES AS SELECTIVE CYCLOOXYGENASE (COX-2) INHIBITORS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 12, pp. 1238–1244, 2013, [Online]. Available: https://sid.ir/paper/630936/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops