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Information Journal Paper

Title

EXPRESSION AND CLINICAL SIGNIFICANCE OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN BREAST CANCER

Pages

  1151-1154

Keywords

ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) 

Abstract

 Objective(s): BREAST CANCER is the most common type of cancer among women worldwide. This study investigated the expression and CLINICAL SIGNIFICANCE of activating transcription factor 3 (ATF3) in human BREAST CANCER and its relationship with the clinical outcome of BREAST CANCER.Materials and Methods: ATF3 expressions were detected in 114 primary BREAST CANCER tissues and 114 adjacent normal tissues using IMMUNOHISTOCHEMISTRY (IHC) assay. Categorical variables were statistically compared by chi-square or Fisher’s exact test. Survival curves were evaluated using the Kaplan-Meier method and comparisons of survival rates were tested using a Log-rank test.Results: IHC analysis showed that the positive expression of ATF3 protein was detected in BREAST CANCER tissue with a positive ratio of 76.3%, and the positive ATF3 expression in adjacent normal breast tissue was 13.2%, which is lower than that in BREAST CANCER tissue samples (P<0.01). Furthermore, ATF3 expression showed significant correlation with TNM stage, invasion, lymph node metastasis and number of metastatic lymph nodes (P=0.038, P=0.029, P=0.026, and P=0.039 respectively), and did not correlate with patients’ age and tumor size (P>0.05). A significant difference in overall survival rate was found between the patients with positive expression of ATF3 protein and those with negative expression (P=0.041).Conclusion: Increased ATF3 expression participate in the tumorigenesis, invasion and metastasis of BREAST CANCER, and ATF3 may be useful as a new PROGNOSTIC INDICATOR for BREAST CANCER patients.

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    • Cite

    APA: Copy

    CAO, HUA, YANG, ZHI XUE, & JIANG, GUO QIN. (2013). EXPRESSION AND CLINICAL SIGNIFICANCE OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN BREAST CANCER. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(11), 1151-1154. SID. https://sid.ir/paper/631165/en

    Vancouver: Copy

    CAO HUA, YANG ZHI XUE, JIANG GUO QIN. EXPRESSION AND CLINICAL SIGNIFICANCE OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN BREAST CANCER. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2013;16(11):1151-1154. Available from: https://sid.ir/paper/631165/en

    IEEE: Copy

    HUA CAO, ZHI XUE YANG, and GUO QIN JIANG, “EXPRESSION AND CLINICAL SIGNIFICANCE OF ACTIVATING TRANSCRIPTION FACTOR 3 IN HUMAN BREAST CANCER,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 16, no. 11, pp. 1151–1154, 2013, [Online]. Available: https://sid.ir/paper/631165/en

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