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Title

THE AMELIORATIVE EFFECTS OF SESAMOL AGAINST SEIZURES, COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS IN THE EXPERIMENTAL MODEL OF EPILEPSY

Pages

  100-107

Abstract

 Objective(s): A growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against COGNITIVE IMPAIRMENT. SESAMOL has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in EPILEPSY which is commonly associated with OXIDATIVE STRESS and COGNITIVE IMPAIRMENT.Materials and Methods: Male Wistar RATs received pentylenetetrazole (PTZ) (30 mg/kg, IP) once every other day until the development of KINDLING, i.e., the occurrence of stage 5 of seizures for three consecutive trials. After the completion of KINDLING procedure, behavioural tests including elevated plus maze and passive avoidance were performed in order to assess learning and memory. OXIDATIVE STRESS was assessed by estimation of lipid peroxidation and reduced glutathione. The effects of pretreatment with SESAMOL (10, 20, and 30 mg/kg, IP) against PTZ-induced seizures, COGNITIVE IMPAIRMENT and OXIDATIVE STRESS were investigated.Results: 32.45±1.86 days after treatment with PTZ, KINDLING was developed that was associated with myoclonic jerks and generalized tonic-clonic seizures. Moreover, PTZ KINDLING induced a remarkable COGNITIVE IMPAIRMENT and OXIDATIVE STRESS. SESAMOL (30 mg/kg) significantly delayed the development of KINDLING and prevented seizure-induced COGNITIVE IMPAIRMENT and OXIDATIVE STRESS.Conclusion: SESAMOL exerts ameliorative effects in the experimental model of EPILEPSY. This phytochemical may be considered as a beneficial adjuvant for antiepileptic drugs.

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    APA: Copy

    HASSANZADEH, PARICHEHR, ARBABI, ELHAM, & ROSTAMI, FATEMEH. (2014). THE AMELIORATIVE EFFECTS OF SESAMOL AGAINST SEIZURES, COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS IN THE EXPERIMENTAL MODEL OF EPILEPSY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(2), 100-107. SID. https://sid.ir/paper/631174/en

    Vancouver: Copy

    HASSANZADEH PARICHEHR, ARBABI ELHAM, ROSTAMI FATEMEH. THE AMELIORATIVE EFFECTS OF SESAMOL AGAINST SEIZURES, COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS IN THE EXPERIMENTAL MODEL OF EPILEPSY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(2):100-107. Available from: https://sid.ir/paper/631174/en

    IEEE: Copy

    PARICHEHR HASSANZADEH, ELHAM ARBABI, and FATEMEH ROSTAMI, “THE AMELIORATIVE EFFECTS OF SESAMOL AGAINST SEIZURES, COGNITIVE IMPAIRMENT AND OXIDATIVE STRESS IN THE EXPERIMENTAL MODEL OF EPILEPSY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 2, pp. 100–107, 2014, [Online]. Available: https://sid.ir/paper/631174/en

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