ELLAGIC ACID IMPROVES HYPERALGESIA AND COGNITIVE DEFICIENCY IN 6-HYDROXIDOPAMINE INDUCED RAT MODEL OF PARKINSON’S DISEASE

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DOLATSHAHI MOJTABA; FARBOOD YAGHOOB; SARKAKI ALIREZA; MANSOURI SEYED MOHAMMAD TAQHI; KHODADADI ALI

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:1 Page(s): 38-46

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Title

ELLAGIC ACID IMPROVES HYPERALGESIA AND COGNITIVE DEFICIENCY IN 6-HYDROXIDOPAMINE INDUCED RAT MODEL OF PARKINSON’S DISEASE

Author(s)

Keywords

6-OHDA

COGNITION

ELLAGIC ACID

PAIN

PARKINSON'S DISEASE

RAT

Abstract

Objective(s): PARKINSON'S DISEASE (PD) is known for motor impairments. But often, there are non-motor symptoms such as cognitive deficiency and PAIN misperception, owing to possible role of nigrostriatal pathway. Antioxidants have protective effect on free radical-induced neuronal damage in PD. To further address, we examined the effects of ELLAGIC ACID (EA) in a RAT model of PD induced by 6-hydroxidopamine (6-OHDA).Materials and Methods: Right medial forebrain bundle (MFB) was lesioned by injecting 6-OHDA (16 mg/2 ml), in PD–animals. Sham operated animals received vehicle instead of 6-OHDA. PD was approved by apomorphine-induced contralateral rotation. EA (50 mg/kg/2 ml, PO, for 10 days) was administered to PD-EA group. Some PD-animals received pramipexole (PPX; 2 mg/kg/2 ml, PO) as a positive control group. Analgesia was measured by tail-flick and hot-plate tests. Passive avoidance task was measured by shuttle box apparatus to record the initial and step-through latency. Spatial COGNITION task was evaluated by Morris water maze test, measuring the escape latency time, path length, swimming speed and time spent in target quadrant.Results: MFB-lesioned RATs showed hyperalgesic responses to the stimulus in tail-flick and hot-plate tests. Also they showed memory and learning deficit in cognitive tests. These effects reversed by EA treatment.Conclusion: 6-OHDA can induce oxidative stress and can disrupt the neural mechanisms underlying proper integration of PAINful stimuli and cognitive processes in MFB-lesioned RATs. Consequently, nigrostriatal pathway can play possible role in nociception and COGNITION. EA, a natural antioxidant, has neuroprotective effect on this pathway and can ameliorate this defect and be considered in PD management.

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APA: Copy

DOLATSHAHI, MOJTABA, FARBOOD, YAGHOOB, SARKAKI, ALIREZA, MANSOURI, SEYED MOHAMMAD TAQHI, & KHODADADI, ALI. (2015). ELLAGIC ACID IMPROVES HYPERALGESIA AND COGNITIVE DEFICIENCY IN 6-HYDROXIDOPAMINE INDUCED RAT MODEL OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(1), 38-46. SID. https://sid.ir/paper/637604/en

Vancouver: Copy

DOLATSHAHI MOJTABA, FARBOOD YAGHOOB, SARKAKI ALIREZA, MANSOURI SEYED MOHAMMAD TAQHI, KHODADADI ALI. ELLAGIC ACID IMPROVES HYPERALGESIA AND COGNITIVE DEFICIENCY IN 6-HYDROXIDOPAMINE INDUCED RAT MODEL OF PARKINSON’S DISEASE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(1):38-46. Available from: https://sid.ir/paper/637604/en

IEEE: Copy

MOJTABA DOLATSHAHI, YAGHOOB FARBOOD, ALIREZA SARKAKI, SEYED MOHAMMAD TAQHI MANSOURI, and ALI KHODADADI, “ELLAGIC ACID IMPROVES HYPERALGESIA AND COGNITIVE DEFICIENCY IN 6-HYDROXIDOPAMINE INDUCED RAT MODEL OF PARKINSON’S DISEASE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 1, pp. 38–46, 2015, [Online]. Available: https://sid.ir/paper/637604/en

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