مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DIFFERENTIATION POTENTIAL OF O BOMBAY HUMAN-INDUCED PLURIPOTENT STEM CELLS AND HUMAN EMBRYONIC STEM CELLS INTO FETAL ERYTHROID-LIKE CELLS

Pages

  426-439

Abstract

 Objective: There is constant difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of "universal" red blood cells. Advances in somatic cell reprogramming of human-INDUCED PLURIPOTENT STEM CELLS (hiPSCs) have provided a valuable alternative source to differentiate into any desired cell type as a therapeutic promise to cure many human disease.Materials and Methods: In this experimental study, we examined the erythroid DIFFERENTIATION potential of normal Bombay hiPSCs (B-hiPSCs) and compared results to human embryonic stem cell (hESC) lines. Because of lacking ABO blood group expression in B-hiPSCs, it has been highlighted as a valuable source to produce any cell type in vitro.Results: Similar to hESC lines, HEMANGIOBLASTS derived from B-hiPSCs expressed approximately 9% KDR+CD31+ and approximately 5% CD31+CD34+. In semisolid media, iPSC and hESC-derived hemangioblast formed mixed type of hematopoietic colony. In mixed colonies, erythroid progenitors were capable to express CD71+GPA+HbF+ and accompanied by endothelial cells DIFFERENTIATION.Conclusion: Finally, iPS and ES cells have been directly induced to erythropoiesis without hemangioblast formation that produced CD71+HbF+erythroid cells. Although we observed some variations in the efficiency of hematopoietic DIFFERENTIATION between iPSC and ES cells, the pattern of DIFFERENTIATION was similar among all three tested lines.

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    Cite

    APA: Copy

    GANJI, FATEMEH, ABROUN, SAEID, BAHARVAND, HOSSEIN, AGHDAMI, NASSER, & EBRAHIMI, MARZIEH. (2015). DIFFERENTIATION POTENTIAL OF O BOMBAY HUMAN-INDUCED PLURIPOTENT STEM CELLS AND HUMAN EMBRYONIC STEM CELLS INTO FETAL ERYTHROID-LIKE CELLS. CELL JOURNAL (YAKHTEH), 16(4 (64)), 426-439. SID. https://sid.ir/paper/631437/en

    Vancouver: Copy

    GANJI FATEMEH, ABROUN SAEID, BAHARVAND HOSSEIN, AGHDAMI NASSER, EBRAHIMI MARZIEH. DIFFERENTIATION POTENTIAL OF O BOMBAY HUMAN-INDUCED PLURIPOTENT STEM CELLS AND HUMAN EMBRYONIC STEM CELLS INTO FETAL ERYTHROID-LIKE CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2015;16(4 (64)):426-439. Available from: https://sid.ir/paper/631437/en

    IEEE: Copy

    FATEMEH GANJI, SAEID ABROUN, HOSSEIN BAHARVAND, NASSER AGHDAMI, and MARZIEH EBRAHIMI, “DIFFERENTIATION POTENTIAL OF O BOMBAY HUMAN-INDUCED PLURIPOTENT STEM CELLS AND HUMAN EMBRYONIC STEM CELLS INTO FETAL ERYTHROID-LIKE CELLS,” CELL JOURNAL (YAKHTEH), vol. 16, no. 4 (64), pp. 426–439, 2015, [Online]. Available: https://sid.ir/paper/631437/en

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