COMPARISON OF DIFFERENT DOSES OF ANESTHESIA INDUCTION BASED UPON BISPECTORAL INDEX MONITORING

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NADERI BAHRAM; HAGHIGHI MOHAMMAD; SEDDIGHINEZHAD ABBAS; MOHAMMADZADEH ALI

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2007 | Volume:29 | Issue:60 Page(s): 37-42

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Title

COMPARISON OF DIFFERENT DOSES OF ANESTHESIA INDUCTION BASED UPON BISPECTORAL INDEX MONITORING

Author(s)

NADERI BAHRAM | HAGHIGHI MOHAMMAD | SEDDIGHINEZHAD ABBAS | MOHAMMADZADEH ALI | Issue Writer Certificate

Keywords

REMIFENTANYLQ3

PROPOFOLQ3

BIS INDEXQ2

DEPTH OF ANESTHESIAQ2

Abstract

Background: PROPOFOL as a new intravenous hypnotic drug in combination with a short acting opioid have been used in total intravenous anesthesia (TIVA). The BIS provides additional information for standard monitoring techniques that helps guiding administration of hypnotic agents.Objective: The comparison of different PROPOFOL dose for anesthesia induction based on BIS (bispectoral index) monitoringMaterials and methods: Forty five patients with ASA I, II undergoing by fracture surgery were randomly assigned to 3 groups. Group A with a PROPOFOL dose of 1 mg/kg. Group B at a dose of 1.5 mg/kg and group C at a dose of 2 mg/kg were studied. REMIFENTANYL 0.5 mg/kg was added to PROPOFOL as opioid drug. The method of BIS INDEX (50-60) has been used for determination of consciousness level and the depth of sleep for achieving the appropriate dose of PROPOFOL. The patients were evaluated to determine concerning the increased HR, occurence of hypotension, bradycardia and the presence of movement duruing intubation as well as the autonomic signs.Results: The mean levels of BIS were 58.8±9.85 in the group A, 50.2±6.55 in group Band 44±5.65 in group C. A comparison between the mean levels of BIS revealed that the group A was significantly different with the other two groups (p=0.009). Optimum level of BIS were significantly different in all 3 groups. Group B: 66.7%, group A: 40%, group C: 20% (less than of all groups) (p=0.034). Hypertension following intubation has seen in 33.3% group A (greatest level) and in 6.7% of group B, and in C group, no hypertension detected that was significantly different (p=0.018). Regarding the need for PROPOFOL repeated dose, there was a significant difference in group A, there was a need for PROPOFOL repeat 40% of cases, and in groups Band C, was not obsereved (p<0.001). Tachycardia, bradycardia, hypotension, movement and autonomic signs, had no significantly differences between 3 groups.Conclusion: It was appeared that group A is not appropriate due to incompatible with BIS, and the need for repeated PROPOFOL dose and hypertension. Considering the best BIS level in group B and lack of any benefit in group C for PROPOFOL repeated in achieving the optimum level of BIS (50-60), it can be concluded that group B with PROPOFOL 1.5 mg/kg is the best dose for achieving the desired level of BIS with REMIFENTANYL at the mentioned dose.

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APA: Copy

NADERI, BAHRAM, HAGHIGHI, MOHAMMAD, SEDDIGHINEZHAD, ABBAS, & MOHAMMADZADEH, ALI. (2007). COMPARISON OF DIFFERENT DOSES OF ANESTHESIA INDUCTION BASED UPON BISPECTORAL INDEX MONITORING. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 29(60), 37-42. SID. https://sid.ir/paper/63191/en

Vancouver: Copy

NADERI BAHRAM, HAGHIGHI MOHAMMAD, SEDDIGHINEZHAD ABBAS, MOHAMMADZADEH ALI. COMPARISON OF DIFFERENT DOSES OF ANESTHESIA INDUCTION BASED UPON BISPECTORAL INDEX MONITORING. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2007;29(60):37-42. Available from: https://sid.ir/paper/63191/en

IEEE: Copy

BAHRAM NADERI, MOHAMMAD HAGHIGHI, ABBAS SEDDIGHINEZHAD, and ALI MOHAMMADZADEH, “COMPARISON OF DIFFERENT DOSES OF ANESTHESIA INDUCTION BASED UPON BISPECTORAL INDEX MONITORING,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 29, no. 60, pp. 37–42, 2007, [Online]. Available: https://sid.ir/paper/63191/en

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